Actively Recruiting
Efficacy of a Topical Palmitated Formulation of Capsaicin (Capsadyn®) In the Treatment of Diabetic Neuropathic Foot Pain
Led by Carilion Clinic · Updated on 2026-04-20
80
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to assess whether the use of a topical cream with an active ingredient can reduce the amount of foot pain experienced in participants who have been diagnosed with Diabetic Peripheral Neuropathy (DPN) with minimal side effects or discomfort from use.
CONDITIONS
Official Title
Efficacy of a Topical Palmitated Formulation of Capsaicin (Capsadyn®) In the Treatment of Diabetic Neuropathic Foot Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 3 toes per foot
- Feet must be otherwise intact
- No eczema, hyperkeratosis, scleroderma, or other skin conditions affecting the area of cream application
- Agree to apply the cream to painful areas of feet as directed
- Agree to apply the cream twice daily
- Willing to wait 60 minutes after application before filling out pain rating forms
- Willing to wait at least 60 minutes before washing feet after application unless burning occurs
- Willing to use cream in a blinded manner
You will not qualify if you...
- Younger than 25 or older than 75 years
- Any skin condition that may disrupt skin integrity or alter sensation in the feet
- Any open wounds, skin ulcers, infections, irritation, eczema, trauma, or burns on feet within 30 days
- Recent foot surgery
- Use of any topical foot medications or creams (including holistic, cannabinoid, prescription, or OTC) unless stable prior to study
- Current substance abuse
- Allergy or hypersensitivity to chili peppers, coconut oil, Shea butter, or sunflower seed oil
- Use of concurrent foot pain therapies that might interfere with pain assessments (except physical therapy or exercise)
- Participation in another clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Carilion Clinic
Roanoke, Virginia, United States, 24016
Actively Recruiting
Research Team
A
Autumn Weidman
CONTACT
A
Adam Cordell
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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