Actively Recruiting
The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans
Led by Henry Ford Health System · Updated on 2025-09-09
5
Participants Needed
1
Research Sites
302 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There are currently no effective treatments for lichen planus pigmentosus (LPP) and erythema dyschromicum perstans (EDP). Tranexamic acid, which may downregulate pigmentation through a reduction in plasmin, has been shown to decrease pigmentation in patients with melasma, another pigmentary disorder. Given that LPP, EDP, and melasma are all disorders of pigmentation with dermal involvement, it is possible that tranexamic acid can also reduce pigmentation in LPP and EDP as well.
CONDITIONS
Official Title
The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of lichen planus pigmentosus, erythema dyschromicum perstans, or ashy dermatosis
- Able to understand the study requirements and risks
- Able to sign a consent form
- Discontinued all topical or oral pigmentation treatments except sunscreen at least one month before treatment
You will not qualify if you...
- Personal history of clotting disorders or thromboembolic diseases (e.g., deep vein thrombosis, stroke)
- Active cancer, excluding non-melanoma skin cancer
- Moderate to severe kidney impairment
- History of migraine with aura
- Current use of anticoagulant medications
- Use of hormonal contraception or hormone replacement therapy within the past 30 days
- Women who are lactating, pregnant, or planning pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
New Center One
Detroit, Michigan, United States, 48202
Actively Recruiting
Research Team
A
Angela Parks-Miller, RN
CONTACT
J
Jennifer Creasor, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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