The Analgesic Mechanism and Recent Clinical Application of Erector Spinae Plane Block: A Narrative Review.
Jing Han Yang, Ye Sun, Yi Ran Yang...
https://pubmed.ncbi.nlm.nih.gov/39308995Actively Recruiting
Phase Not Applicable
Age: 18Years - 64Years
All Genders
ID07560267
Efficacy of Ultrasound-Guided Erector Spinae Plane Block in Postoperative Pain Management in Nephrectomy: A Randomized Controlled Trial
Led by Bangladesh Medical University · Updated on 2026-05-01
66
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the ultrasound-guided erector spinae plane (ESP) block as a method to manage postoperative pain in adults undergoing open nephrectomy, which is kidney removal surgery. This trial compares the ESP block to traditional pain relief methods such as opioids to see if it can reduce pain and lower opioid use after surgery. The study involves 66 adult patients and aims to improve recovery by finding safer pain management options. Participants are randomly assigned to one of two groups. The control group receives general anesthesia with conventional pain management including opioids and standard local anesthetics. The intervention group receives general anesthesia plus the ultrasound-guided ESP block, administered before anesthesia induction. The ESP block involves injecting a local anesthetic into the erector spinae muscle area using ultrasound guidance to target pain relief. During the study, researchers will measure pain using the Visual Analogue Scale (VAS) at multiple time points within the first 24 hours after surgery. They will also track total opioid use, heart rate, blood pressure, mean arterial pressure, and peak expiratory flow rate before and after surgery to assess respiratory function and hemodynamic stability. These assessments aim to determine if the ESP block can provide better pain control and reduce opioid needs, enhancing patient recovery after nephrectomy.
CONDITIONS
Brief Title
Efficacy of Ultrasound-Guided Erector Spinae Block for Postoperative Pain Management in Nephrectomy
Who Can Participate
Age: 18Years - 64Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 to 64 years
- Scheduled for open nephrectomy (radical or partial) under general anesthesia
- ASA physical status I-II (American Society of Anesthesiologists classification)
You will not qualify if you...
- Allergy to local anesthetics
- Local infection or inflammation at the site of the block placement
- Presence of anatomical deformities in the spine
- Coagulopathy or any bleeding disorder
- Pregnancy or breastfeeding women
- History of severe chronic pain syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Surgery day plus 24 hours postoperative
Participants undergo open nephrectomy under general anesthesia. The intervention group receives an ultrasound-guided erector spinae plane (ESP) block immediately before anesthesia induction to manage postoperative pain, while the control group receives conventional pain management including opioids.
1 baseline visit on surgery day and multiple assessments within 24 hours after surgery
Post-operative Follow-up
Duration - 24 hours after surgery
Participants are monitored for postoperative pain, opioid consumption, hemodynamic responses, and respiratory function for 24 hours following surgery to evaluate recovery and pain management effectiveness.
Assessments at 0, 1, 3, 6, 12, and 24 hours postoperatively
Trial Site Locations
Total: 1 location
1
Bangladesh Medical University
Dhaka, Bangladesh, 1000
Actively Recruiting
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Research Team
K
Kazi Mahzabin Arin, MD
A
AKM Akhtaruzzaman, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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