Postoperative intravenous morphine titration.
F Aubrun, J-X Mazoit, B Riou
https://pubmed.ncbi.nlm.nih.gov/22250276/Actively Recruiting
Led by Bangladesh Medical University · Updated on 2026-05-01
66
Participants Needed
1
Research Sites
4 weeks
Total Duration
Researchers are evaluating the ultrasound-guided erector spinae plane ESP block as a method to manage postoperative pain in adults undergoing open nephrectomy, which is kidney removal surgery. This trial compares the ESP block to traditional pain relief methods such as opioids to see if it can reduce pain and lower opioid use after surgery. The study involves 66 adult patients and aims to improve recovery by finding safer pain management options. Participants are randomly assigned to one of two groups. The control group receives general anesthesia with conventional pain management including opioids and standard local anesthetics. The intervention group receives general anesthesia plus the ultrasound-guided ESP block, administered before anesthesia induction. The ESP block involves injecting a local anesthetic into the erector spinae muscle area using ultrasound guidance to target pain relief. During the study, researchers will measure pain using the Visual Analogue Scale VAS at multiple time points within the first 24 hours after surgery. They will also track total opioid use, heart rate, blood pressure, mean arterial pressure, and peak expiratory flow rate before and after surgery to assess respiratory function and hemodynamic stability. These assessments aim to determine if the ESP block can provide better pain control and reduce opioid needs, enhancing patient recovery after nephrectomy.
CONDITIONS
Efficacy of Ultrasound-Guided Erector Spinae Block for Postoperative Pain Management in Nephrectomy
K
Kazi Mahzabin Arin, MD
A
AKM Akhtaruzzaman, MD
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Bangladesh Medical University
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day plus 24 hours postoperative
Participants undergo open nephrectomy under general anesthesia. The intervention group receives an ultrasound-guided erector spinae plane (ESP) block immediately before anesthesia induction to manage postoperative pain, while the control group receives conventional pain management including opioids.
1 baseline visit on surgery day and multiple assessments within 24 hours after surgery
Duration - 24 hours after surgery
Participants are monitored for postoperative pain, opioid consumption, hemodynamic responses, and respiratory function for 24 hours following surgery to evaluate recovery and pain management effectiveness.
Assessments at 0, 1, 3, 6, 12, and 24 hours postoperatively
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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