Actively Recruiting
The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ Cell Tumors
Led by Beijing Tiantan Hospital · Updated on 2021-11-18
150
Participants Needed
1
Research Sites
267 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary endpoint 1. three-year disease-free survival of patients with localized basal ganglia germ cell tumors receiving whole-ventricle irradiation 2. Health-related quality of life measured by PedsQL 4.0 and SF-36 Second endpoint 1. three-year overall survival of patients with localized basal ganglia germ cell tumors receiving whole-ventricle irradiation 2. Adverse effects of chemoradiotherapy measured by NCI CTCAE 5.0
CONDITIONS
Official Title
The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ Cell Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 3 and 30 years
- Newly diagnosed unilateral basal ganglia or thalamus lesion
- Histologically confirmed germinoma or non-germinomatous germ cell tumor; or elevated serum/CSF tumor markers as specified
- No additional lesions in the central nervous system on imaging
- Negative cerebrospinal fluid cytology test
- Adequate organ function
- Written informed consent provided
You will not qualify if you...
- Lesions in both basal ganglia or thalamus
- Presence of synchronous pineal or sellar/suprasellar lesions
- Diagnosis of diabetes insipidus
- Presence of extracranial lesions
- Serum or CSF beta-HCG levels greater than 50 IU/L without histological confirmation for germinoma
- Serum or CSF beta-HCG levels between 50 IU/L and 500 IU/L without histological confirmation for non-germinomatous tumors
- Mature teratoma with normal tumor markers
- Inadequate organ function
- Poor compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, China, 100070
Actively Recruiting
Research Team
B
Bo Li, MD,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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