Actively Recruiting

Phase Not Applicable
Age: 18Years +
FEMALE
NCT07170514

EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery

Led by Pest County Flór Ferenc Hospital · Updated on 2026-04-14

200

Participants Needed

3

Research Sites

102 weeks

Total Duration

On this page

Sponsors

P

Pest County Flór Ferenc Hospital

Lead Sponsor

K

Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery. Despite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs. The main questions aim to answer are: * May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method? * What effect might a decrease in mechanical power of ventilation have on postoperative pulmonary complications? Participants will: * Receive an EIT-guided or a Cdyn-guided PEEP titration procedure during laparoscopic gynecological surgery. * Be assessed for mechanical power of ventilation, oxygenation, atelectasis and postoperative pulmonary complications during and 2 days after surgery. * Be followed-up for mortality until the 28th postoperative day.

CONDITIONS

Official Title

EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient scheduled for elective laparoscopic gynaecological surgery
  • Age > 18 years
  • Signed consent to participate in the trial
Not Eligible

You will not qualify if you...

  • Age < 18 years
  • American Society of Anesthesiologists (ASA) physical status IV
  • History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)
  • Uncontrolled bronchial asthma
  • Pulmonary metastases
  • History of any thoracic surgery
  • Need for thoracic drainage before surgery
  • Congestive heart failure (NYHA grades III or IV)
  • Extreme obesity (BMI >35 kg m-2)
  • Lack of patient's consent

AI-Screening

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Trial Site Locations

Total: 3 locations

1

Semmelweis University

Budapest, Budapest, Hungary, 1085

Not Yet Recruiting

2

Semmelweis Hospital Kiskunhalas

Kiskunhalas, Bács-Kiskun county, Hungary, 6400

Not Yet Recruiting

3

Flór Ferenc Hospital Kistarcsa

Kistarcsa, Pest County, Hungary, 2143

Actively Recruiting

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Research Team

Z

Zoltán Ruszkai, MD, PhD

CONTACT

G

Gergely Bokrétás, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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