Actively Recruiting
EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery
Led by Pest County Flór Ferenc Hospital · Updated on 2026-04-14
200
Participants Needed
3
Research Sites
102 weeks
Total Duration
On this page
Sponsors
P
Pest County Flór Ferenc Hospital
Lead Sponsor
K
Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery. Despite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs. The main questions aim to answer are: * May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method? * What effect might a decrease in mechanical power of ventilation have on postoperative pulmonary complications? Participants will: * Receive an EIT-guided or a Cdyn-guided PEEP titration procedure during laparoscopic gynecological surgery. * Be assessed for mechanical power of ventilation, oxygenation, atelectasis and postoperative pulmonary complications during and 2 days after surgery. * Be followed-up for mortality until the 28th postoperative day.
CONDITIONS
Official Title
EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient scheduled for elective laparoscopic gynaecological surgery
- Age > 18 years
- Signed consent to participate in the trial
You will not qualify if you...
- Age < 18 years
- American Society of Anesthesiologists (ASA) physical status IV
- History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)
- Uncontrolled bronchial asthma
- Pulmonary metastases
- History of any thoracic surgery
- Need for thoracic drainage before surgery
- Congestive heart failure (NYHA grades III or IV)
- Extreme obesity (BMI >35 kg m-2)
- Lack of patient's consent
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Semmelweis University
Budapest, Budapest, Hungary, 1085
Not Yet Recruiting
2
Semmelweis Hospital Kiskunhalas
Kiskunhalas, Bács-Kiskun county, Hungary, 6400
Not Yet Recruiting
3
Flór Ferenc Hospital Kistarcsa
Kistarcsa, Pest County, Hungary, 2143
Actively Recruiting
Research Team
Z
Zoltán Ruszkai, MD, PhD
CONTACT
G
Gergely Bokrétás, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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