What is EIT studying for acute respiratory distress syndrome (ARDS)?

EIT is being studied to guide ventilator settings in patients with ARDS after trauma or surgery. Researchers want to see if EIT helps find better PEEP levels to improve oxygen and lung function. The study is led by Nguyen Dang Thu and aims to improve care in this critical condition.

Who may be eligible for this ARDS clinical trial?

Adults aged 18 to 90 years with moderate to severe ARDS related to trauma or surgery may be eligible. Both men and women can participate. Important factors include no severe brain injury, no implanted electrical devices, and no pregnancy or breastfeeding. Please review eligibility criteria for more details.

Is there any cost to participate in this ARDS clinical trial?

Study-related care, including the device use and all trial visits, is provided at no cost. Personal travel or other expenses may vary and are not guaranteed to be covered. Participants can expect their study treatments and assessments free of charge.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 90Years

All Genders

ID07313644

Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Optimization in Patients With Trauma-Related and Postoperative Acute Respiratory Distress Syndrome

Led by Nguyen Dang Thu · Updated on 2026-01-02

Participants Needed

Research Sites

17 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating the use of electrical impedance tomography EIT to guide positive end-expiratory pressure PEEP settings in patients with moderate to severe acute respiratory distress syndrome ARDS following trauma or major surgery. ARDS can be a serious complication requiring mechanical ventilation, but improper ventilator settings may worsen lung injury. This study aims to compare EIT-guided PEEP optimization with the conventional low oxygen and PEEP strategy to improve oxygen levels and respiratory function. The study randomly assigns adult patients to two groups. One group receives PEEP adjustments based on EIT, a bedside imaging device that monitors lung ventilation in real time. This involves sedation, airway suctioning, and a stepwise reduction of PEEP while monitoring lung collapse and overdistension to find the optimal PEEP level. The control group receives PEEP settings according to standard ARDS Network guidelines using a low oxygen and PEEP table. Both groups follow recommended ventilation and oxygenation protocols. Participants will be monitored for oxygenation and lung mechanics at baseline and daily for four days. Secondary measures include survival at 28 days, ventilator-free days, ICU and hospital stay lengths, barotrauma occurrence, use of rescue therapies, and organ function scores. Safety assessments include monitoring for blood pressure drops, oxygen saturation, and arrhythmias during PEEP titration. The trial will continue until December 2026, with comprehensive evaluations to assess the effects of EIT-guided PEEP on clinical outcomes in ARDS patients after trauma or surgery.

CONDITIONS

Brief Title

EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS

Who Can Participate

Age: 18Years - 90Years

All Genders

Eligibility Criteria

You may qualify if you...

Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS.

You will not qualify if you...

Age under 18 or over 90 years.
Severe acute brain injury or acute stroke with Glasgow Coma Scale less than 8.
Thoracic trauma with pneumothorax or pneumomediastinum.
End-stage diseases under palliative care such as metastatic cancer, cirrhosis, or end-stage renal disease.
Severe multiorgan failure with expected survival less than 7 days.
Conditions requiring prolonged mechanical ventilation like Guillain-Barré syndrome or cervical spinal cord injury.
Contraindications to high carbon dioxide levels, e.g., elevated intracranial pressure or acute coronary syndrome.
Prior use of advanced respiratory therapies such as ECMO, inhaled nitric oxide, prone positioning, or high-frequency ventilation.
Pregnancy, breastfeeding, or skin lesions at electrode placement sites.
Implanted electrical devices interfering with EIT, e.g., pacemaker or ICD.
Known allergy to electrode materials.
Refusal to participate or concurrent enrollment in another study.

Research Team

Nguyen Viet Minh

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