Actively Recruiting
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Led by Nguyen Dang Thu · Updated on 2026-01-02
80
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
Sponsors
N
Nguyen Dang Thu
Lead Sponsor
H
Hanoi Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery. Mechanical ventilation is essential for supportive care in this population, but may aggravate lung injury when suboptimal ventilatory settings are applied. Positive end-expiratory pressure (PEEP) is crucial for maintaining alveolar recruitment; however, optimal PEEP selection in trauma- or postoperative-associated ARDS remains uncertain. Electrical impedance tomography (EIT) enables bedside, real-time assessment of regional ventilation and may support optimal PEEP titration by balancing alveolar overdistension and collapse. This study compares EIT-guided PEEP optimization with the conventional low FiO₂-PEEP strategy in terms of oxygenation and respiratory mechanics in patients with moderate to severe ARDS following trauma or surgery.
CONDITIONS
Official Title
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS.
You will not qualify if you...
- Age less than 18 or greater than 90 years.
- Severe acute brain injury or acute stroke with Glasgow Coma Scale less than 8.
- Thoracic trauma with pneumothorax or pneumomediastinum.
- End-stage diseases under palliative care, such as metastatic cancer, cirrhosis, or end-stage renal disease.
- Severe multiorgan failure with expected survival less than 7 days.
- Conditions requiring prolonged mechanical ventilation, like Guillain-Barré syndrome or cervical spinal cord injury.
- Contraindications to hypercapnia, including elevated intracranial pressure or acute coronary syndrome.
- Prior use of advanced respiratory therapies such as ECMO, inhaled nitric oxide, prone positioning, or high-frequency ventilation.
- Pregnancy, breastfeeding, or skin lesions at electrode placement sites.
- Implanted electrical devices interfering with EIT, such as pacemaker or ICD.
- Known allergy to electrode materials.
- Refusal to participate or concurrent enrollment in another study.
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Trial Site Locations
Total: 1 location
1
Center for Anesthesia and Surgical Intensive Care, Viet Duc University Hospital
Hanoi, Vietnam, 10000
Actively Recruiting
Research Team
N
Nguyen Viet Minh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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