Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07372794

EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)

Led by Capital Medical University · Updated on 2026-05-04

200

Participants Needed

1

Research Sites

43 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies. This multicenter randomized controlled trial aims to evaluate whether EIT-guided respiratory physiotherapy improves ventilator-free days at day 28 compared with conventional respiratory physiotherapy in adult patients with PMV. Respiratory physiotherapy consists of airway clearance, chest physiotherapy techniques, breathing pattern optimization, and therapeutic positioning. In the EIT-guided group, real-time EIT imaging is used to individualize physiotherapy strategies based on predefined ventilation distribution indicators, while the control group receives standardized physiotherapy according to institutional protocols without EIT guidance. Secondary outcomes include successful liberation from mechanical ventilation, diaphragm ultrasound parameters, EIT-derived ventilation distribution indices (exploratory mechanistic outcomes), ICU Mobility Scale, healthcare resource utilization, and safety outcomes.

CONDITIONS

Official Title

EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age �3e�3d 18 years
  • Receiving invasive mechanical ventilation for at least 21 consecutive days
  • Clinically stable and eligible for respiratory physiotherapy as determined by the treating team
  • Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment
  • Written informed consent obtained from the patient or legally authorized representative
Not Eligible

You will not qualify if you...

  • Contraindications to electrical impedance tomography
  • Hemodynamic instability requiring high-dose vasoactive support
  • Severe hypoxemia refractory to optimization
  • Unstable fractures or other contraindications to mobilization or positioning
  • Pregnancy
  • Expected death within 48 hours

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Beijing Rehabilitation Hospital Affiliated to Capital Medical University

Beijing, Beijing Municipality, China, 100144

Actively Recruiting

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Research Team

Y

Yi Li

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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