Study of EIT-Guided Ventilator Settings to Lower Mechanical Power in Adults With Acute Hypoxemic Respiratory Failure

What this Trial Is About

Researchers are investigating the use of Electrical Impedance Tomography EIT to guide ventilator settings in patients with acute hypoxemic respiratory failure AHRF, which includes conditions like ARDS, severe pneumonia, and pulmonary edema. The study aims to explore how EIT-guided PEEP titration affects mechanical power, a factor linked to ventilator-induced lung injury VILI, as well as changes in lung mechanics and gas exchange. This exploratory study will enroll 17 patients who require invasive mechanical ventilation. Participants will undergo a standardized EIT-guided PEEP titration using the Enlight 2100 EIT device. The goal is to find the optimal PEEP level that reduces alveolar overdistension and collapse based on real-time EIT readings. Mechanical power and other ventilatory parameters will be measured at baseline and then at 2, 12, and 24 hours after PEEP adjustment. Safety outcomes like hemodynamic stability and complications will also be monitored. During the study, patients will be closely observed with assessments of lung compliance, plateau pressure, driving pressure, ventilation distribution, and gas exchange parameters. They will be followed for up to 28 days to record the duration of mechanical ventilation, ICU stay, and mortality. The primary outcome is the change in mechanical power before and after EIT-guided ventilator adjustment, with multiple secondary outcomes measured over 24 hours. The study aims to evaluate feasibility and gather data for future research.

EIT-Guided Ventilator Settings in AHRF