Actively Recruiting
Using Electrical Impedance Tomography-Guided Ventilator Settings to Reduce Mechanical Power in Acute Hypoxemic Respiratory Failure An Exploratory Study
Led by Mahidol University · Updated on 2025-04-27
17
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the use of Electrical Impedance Tomography (EIT) to guide ventilator settings in patients with acute hypoxemic respiratory failure (AHRF), which includes conditions like ARDS, severe pneumonia, and pulmonary edema. The study aims to explore how EIT-guided PEEP titration affects mechanical power, a factor linked to ventilator-induced lung injury (VILI), as well as changes in lung mechanics and gas exchange. This exploratory study will enroll 17 patients who require invasive mechanical ventilation. Participants will undergo a standardized EIT-guided PEEP titration using the Enlight 2100 EIT device. The goal is to find the optimal PEEP level that reduces alveolar overdistension and collapse based on real-time EIT readings. Mechanical power and other ventilatory parameters will be measured at baseline and then at 2, 12, and 24 hours after PEEP adjustment. Safety outcomes like hemodynamic stability and complications will also be monitored. During the study, patients will be closely observed with assessments of lung compliance, plateau pressure, driving pressure, ventilation distribution, and gas exchange parameters. They will be followed for up to 28 days to record the duration of mechanical ventilation, ICU stay, and mortality. The primary outcome is the change in mechanical power before and after EIT-guided ventilator adjustment, with multiple secondary outcomes measured over 24 hours. The study aims to evaluate feasibility and gather data for future research.
CONDITIONS
Brief Title
EIT-Guided Ventilator Settings in AHRF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with acute hypoxemic respiratory failure within 48 hours
- Expected to require invasive mechanical ventilation for at least 48 hours
- Currently on mechanical ventilation within 24 hours
- Receiving deep sedation and neuromuscular blockade
You will not qualify if you...
- Pregnancy
- Body mass index greater than 40 kg/m2
- Presence of pacemaker or automatic implantable cardioverter-defibrillator (AICD)
- Unable to place EIT belt due to surgical wounds, thoracic or spinal cord trauma, or recent thoracic surgery
- High risk for PEEP titration
- Hemodynamic instability with mean arterial pressure less than 65 mmHg despite treatment
- Unstable cardiac arrhythmias
- Lung bullae larger than 2 cm on chest X-ray
- Pneumothorax or pneumomediastinum
- Right-sided heart failure or severe pulmonary hypertension
- Neurologic conditions that risk intracranial hypertension
- Use of extracorporeal membrane oxygenation (ECMO)
- Severe chronic respiratory disease with specified lung function or clinical criteria
- Decision to withhold life-sustaining treatment or palliative care
- Expected survival less than 24 hours
- Refusal to provide informed consent
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 24 hours
Participants undergo ventilator adjustments using Electrical Impedance Tomography (EIT)-guided PEEP titration to optimize mechanical power and lung mechanics.
Assessments at baseline, 2 hours, 12 hours, and 24 hours after ventilator adjustment
Duration - Up to 28 days
Participants are followed for up to 28 days to monitor duration of mechanical ventilation, ICU stay, and survival.
Ongoing monitoring during ICU stay and up to 28 days
Trial Site Locations
Total: 1 location
1
Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700
Actively Recruiting
Research Team
J
Jitanong Sootlek, MD, PCCM
R
Ranistha Ratanarat, MD, Nephrology, Critical care
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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