Actively Recruiting
Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA
Led by University of Padova · Updated on 2025-07-08
40
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Protective ventilatory strategy should be applied to reduce ventilator-induced lung injury (VILI) after Lung Transplantation (LTx) or in case of acute respiratory failure requiring invasive mechanical ventilation. Neurally Adjusted Ventilatory Assist (NAVA) is an assisted ventilation mode in which respiratory support is coordinated by the electrical activity of the diaphragm (EAdi). Aim of the study is to assess the physiological relationship between neural respiratory drive, as assessed by EAdi, and tidal volume, driving pressure, and mechanical power, at different levels of ventilatory assist, in the absence of pulmonary vagal afferent feedback or during acute respiratory failure. Additional parameters will be collected: Pmus, Pocc, transpulmonary pressure etc.
CONDITIONS
Official Title
Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Admitted to ICU for post-operative monitoring after lung transplantation or acute respiratory failure needing invasive mechanical ventilation
- Presence of spontaneous breathing activity
- Sedation titrated to a target Richmond Agitation-Sedation Scale (RASS) between 0 and -2
- Written informed consent obtained
You will not qualify if you...
- Contraindication to nasogastric tube insertion (such as gastroesophageal surgery in the previous 3 months, gastroesophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma)
- Increased risk of bleeding with nasogastric tube insertion due to severe coagulation disorders or severe thrombocytopenia (INR > 2 and platelets count < 70,000/mm3)
- Severe hemodynamic instability (noradrenaline > 0.3 mcg/kg/min and/or use of vasopressin)
- Postoperative extracorporeal respiratory support (ECMO)
- Pre-operative reconditioning of transplanted lungs by ex-vivo lung perfusion (EVLP)
- Lung retransplantation
- Failure to obtain a stable electrical activity of the diaphragm (EAdi) signal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute of Anaesthesia and Intensive Care, Padua University hospital
Padova, Italy, Italy, 35120
Actively Recruiting
Research Team
A
Annalisa Boscolo, MD
CONTACT
N
Nicolò Sella, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here