Electrical impedance myography in individuals with collagen 6 and laminin α-2 congenital muscular dystrophy: a cross-sectional and 2-year analysis.
Carmel Nichols, Minal S Jain, Katherine G Meilleur...
https://pubmed.ncbi.nlm.nih.gov/28224647Actively Recruiting
Phase Not Applicable
Age: 2Years - 110Years
All Genders
Healthy Volunteers
ID01900132
Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy Volunteers
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-06-05
275
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying electrical impedance myography (EIM), a new, noninvasive technique that uses a mild electrical current to examine muscles and nerves in people with neuromuscular diseases as well as healthy individuals. The study aims to gain experience with the EIM device, understand its ability to distinguish different neuromuscular disorders in adults and children, and explore its potential as a biomarker in clinical studies. Healthy volunteers help establish normal values and reproducibility of the test. Participants will undergo EIM testing where the device and small electrodes are placed on the skin to deliver a painless electrical current. Some may also have ultrasound exams, nerve conduction studies with small shocks, and electromyography involving a thin needle in the muscle for adults. The study includes one clinic visit lasting 2 to 3 hours with possible follow-up visits to repeat tests and track changes over time. During the study visit, participants will have medical history and physical exams, followed by the various tests described. Researchers will collect data on EIM measurements, ultrasound, and nerve tests to compare results and evaluate the device's usefulness. The study will monitor changes in EIM parameters over time, especially in children, and aims to develop standard reference values. Participants' involvement typically lasts a few hours per visit, with some returning for additional testing as needed.
CONDITIONS
Brief Title
Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers
Who Can Participate
Age: 2Years - 110Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 18 years or older in good general health
- Healthy children aged 7 to 18 years in good general health
- Adults and children aged 2 years or older with suspected neuromuscular disorders such as motor neuron disease, myopathy, neuropathy, or movement disorders
- Ability and willingness to sign informed consent and comply with study procedures
- NIH employees may participate except those working in the EMG Section, OCD, NINDS
You will not qualify if you...
- Healthy adults with medical conditions or medications affecting muscle or nerve function, including diabetes, kidney or liver disease
- Healthy adults with history of stroke, muscle disorders, peripheral neuropathy, or spine surgery
- Healthy children with medical conditions or medications affecting muscle or nerve function, including diabetes, kidney or liver disease
- Healthy children with history of stroke, muscle disorders, peripheral neuropathy, or spine surgery
- Individuals with no clinical evidence of neuromuscular disorder on evaluation (for those with suspected disease)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Single session of 2 to 3 hours
Participants undergo evaluation using the Electrical Impedance Myography (EIM) device, ultrasound, nerve conduction studies, and electromyography (EMG) to assess neuromuscular function.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 2 years for pediatric subjects; total study duration up to 10 years
A subset of pediatric participants and neuromuscular disorder patients may be followed with serial studies to monitor changes over time and evaluate the utility of EIM as a biomarker.
Repeat visits as requested, timing varies
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
C
Candida C Silva
T
Tanya J Lehky, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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Published Research Related To This Trial
Electrical impedance myography discriminates congenital muscular dystrophy from controls.
Daniel P Schwartz, Jahannaz Dastgir, Anam Salman...
https://pubmed.ncbi.nlm.nih.gov/26179210Electrical impedance myography (EIM) in a natural history study of C9ORF72 mutation carriers.
Michelle B Offit, Tianxia Wu, Mary Kay Floeter...
https://pubmed.ncbi.nlm.nih.gov/32312103