Study of Electrical Impedance Myography to Understand Neuromuscular Disorders and Healthy Muscle Function in Both Children and Adults

What this Trial Is About

Researchers are studying electrical impedance myography EIM, a new, painless technique that measures how a mild electrical current passes through muscles to evaluate neuromuscular disorders. The study includes both healthy volunteers and individuals with various neuromuscular diseases to compare EIM results with standard tests. The goal is to understand if EIM can differentiate types of neuromuscular disorders and to establish reproducible, normative values across different ages and populations. Participants will undergo testing using the EIM device, which involves placing electrodes on the skin to deliver a high-frequency current. Additional tests may include nerve and muscle ultrasonography, nerve conduction studies, and electromyography EMG with a thin needle for adults. Testing sessions typically last up to three hours, with healthy volunteers and patients possibly returning for follow-up visits to assess reproducibility and monitor changes over time. Participants will have one or more clinic visits involving medical history, physical exams, and various muscle and nerve assessments. Researchers will collect data on EIM measures, ultrasound, and other electrodiagnostic methods to evaluate their relationships and utility. The study aims to track changes in specific parameters over time, especially in pediatric patients, with a total study duration extending up to 10 years. Safety and comfort are prioritized, and the procedures are noninvasive or minimally invasive.

Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers