Actively Recruiting
Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn Infants
Led by University Children's Hospital Basel · Updated on 2026-05-08
86
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how to find the best level of positive end-expiratory pressure (PEEP) for newborn infants who need respiratory support. This study focuses on infants between 22 weeks and 41 weeks and 6 days gestational age who require mechanical ventilation. The goal is to improve understanding of how to adjust PEEP to reduce lung injury and long-term breathing problems. The study uses three diagnostic tools to measure lung function: electrical impedance tomography (EIT), forced oscillation technique (FOT), and the saturation oxygenation pressure index (SOPI). These tools help track lung aeration, lung mechanics, and oxygenation effects depending on PEEP. Measurements happen once daily for the first three days of respiratory support and then weekly if the infant remains on ventilation, with an extra measurement after extubation. Participants will have lung function assessed regularly through these non-invasive methods. The research team will monitor changes in composite scores from EIT, FOT, and SOPI, as well as other lung function measures like tidal volume and respiratory rate. Data is collected during mechanical ventilation and after extubation, typically over about one month. This monitoring aims to identify the optimal PEEP settings to support newborn lung health safely.
CONDITIONS
Brief Title
Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Born between 22 weeks and 0 days to 41 weeks and 6 days gestational age
- Requires mechanical ventilation
- Written informed parental consent obtained
You will not qualify if you...
- Major congenital malformations including lung and cardiac malformations
- Receiving high frequency oscillatory ventilation
- Lack of written informed parental consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Once daily during the first three days on respiratory support and repeated weekly if the infant remains mechanically ventilated, approximately 1 month
Participants on respiratory support undergo daily measurements of electrical impedance tomography (EIT), forced oscillation technique (FOT), and saturation oxygenation pressure index (SOPI) to identify optimal positive end-expiratory pressure (PEEP). These assessments help understand lung aeration, lung mechanics, and ventilation to perfusion ratio.
Daily visits for 3 days, then weekly visits for up to 1 month
Duration - Single assessment after extubation
An additional measurement is performed after extubation to assess lung function post-respiratory support.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Department of Neonatology, University Children's Hospital Basel UKBB
Basel, Switzerland, 4031
Actively Recruiting
Research Team
R
Roland Gerull, Dr. med.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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