Actively Recruiting
Electroclinical Correlates in Essential Tremor
Led by University Hospital, Bordeaux · Updated on 2024-11-01
10
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Bordeaux
Lead Sponsor
M
MINDig
Collaborating Sponsor
AI-Summary
What this Trial Is About
Essential tremor (ET) is a neurological disorder that affects nearly 0.9% of the world's population. High-frequency Deep Brain Stimulation (DBS) of the ventral-intermediate nuclei of the thalamus (VIM) has been proven as an effective second-line treatment for severe forms of ET. The arrival on the market of the PERCEPT™ (new stimulator/recorder, Medtronic, Minneapolis, USA) now allows, in addition to the stimulation delivery, the recording of intracerebral activity at a distance from surgery, in a non-invasive way and in ecological condition at home. Investigators aim at recording the variations of thalamic Local Field Potentials (LFP) oscillations, in ecological condition, during rest and movement, with and without deep brain stimulation, once a week, between M3 and M6 post surgery.
CONDITIONS
Official Title
Electroclinical Correlates in Essential Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Advanced disabling and drug-resistant tremor
- Receiving deep brain stimulation treatment with implantation of the PERCEPT12 device according to standard care
- Chronic progressive cardiac, renal, hematological or pulmonary diseases under treatment
- Patient aged between 18 to 75 years
- Normal brain MRI
- MATTIS score 9 130/144 or MOCA 9 24/30
- Subject affiliated with or benefiting from a social security plan
- Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research)
You will not qualify if you...
- Major depressive syndrome (Beck scale > 20)
- MRI showing significant brain atrophy or significant hypersignals
- Pregnant or breastfeeding women
- Being unable to give personal consent
- Be subject to a measure of legal protection (curatorship, guardianship) or placed under judicial protection.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU de Bordeaux
Bordeaux, France, 33076
Actively Recruiting
Research Team
E
Edouard COURTIN, Dr
CONTACT
O
Olivier Branchard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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