Study of Anxiety and Brain Activity in Adults with Drug-Resistant Epilepsy Using Intracerebral EEG

What this Trial Is About

Anxiety disorders are the most common mental health conditions and can cause significant personal and financial challenges. Current treatments often do not fully relieve anxiety symptoms. This research focuses on understanding the brain mechanisms behind pathological anxiety, especially in patients with drug-resistant epilepsy who also have generalized anxiety disorder GAD. The study compares patients with drug-resistant epilepsy with and without GAD to explore these mechanisms. The study uses intracerebral electroencephalographic recordings stereoelectroencephalography or sEEG performed during a pre-surgical assessment for epilepsy. Participants will complete a specially designed task exposing them to anxiety-provoking scenarios based on their own anxious thoughts. These sessions will be monitored using sEEG, physiological stress measures, and anxiety level ratings to study brain activity and responses during anxiety exposure. Participants will undergo various assessments including neuropsychiatric evaluations and multiple anxiety and depression rating scales. Researchers will measure changes in brain activity within key brain networks involved in anxiety, and correlate these findings with clinical features and task performance. The study will monitor outcomes such as anxiety severity and cognitive function during the inclusion phase. The total study duration and follow-up details are aligned with the pre-surgical evaluation period.

Electroclinical Correlation of Anxiety