Observing Seizure Risk and Safety of EEG Monitoring in Critically Ill Children at Childrens Hospital of Philadelphia

What this Trial Is About

This research aims to study electrographic seizures in critically ill children in the Pediatric ICU, focusing on identifying risk factors and evaluating current seizure management strategies. The study is a single-center, prospective observational trial conducted at the Childrens Hospital of Philadelphia CHOP. It seeks to develop prediction models to guide EEG monitoring resources toward children at highest risk for seizures and to assess the safety of the seizure management pathway used at CHOP. Children enrolled in this study undergo clinically indicated continuous EEG monitoring to detect electrographic seizures. Some participants may receive seizure management based on standard clinical decisions guided by the CHOP ICU EEG Monitoring Pathway. The study tracks these patients to understand seizure occurrence and the safety of current management practices without altering or assigning treatments. Participants are observed during their EEG monitoring period, and data are collected on seizure occurrence within 3 days. Safety outcomes including mortality, cardiopulmonary adverse effects, organ dysfunction, and hospital-acquired infections are monitored for 5 days. The study involves reviewing clinical data without additional interventions, aiming to improve understanding of seizure risk and management in critically ill children over the study duration.

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children