Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

What this Trial Is About

Electrographic seizures frequently occur in critically ill children and often require continuous EEG monitoring, which uses significant resources. Researchers are studying these seizures to identify risk factors and improve management strategies, as current data on the best anti-seizure medications and approaches is limited. This single-center observational study takes place at the Children's Hospital of Philadelphia and aims to create prediction models to guide EEG monitoring and evaluate the safety of current seizure management. Participants in this study are critically ill children in the Pediatric ICU undergoing clinically indicated continuous EEG monitoring. The study observes their electrographic seizure management practices following the hospital's ICU EEG Monitoring Pathway. There are no experimental treatments; instead, the study tracks EEG monitoring and seizure interventions as they naturally occur to collect data on risk factors and safety. During the study, children receive clinically required EEG monitoring and seizure management as part of their care. Researchers collect data on seizure occurrence over three days and monitor safety outcomes such as mortality, cardiopulmonary effects, organ dysfunction, and hospital-acquired infections over five days. The study does not interfere with treatment and focuses on understanding seizure risks and management outcomes over the observation period.

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children