Actively Recruiting
Electrophysiological Biomarkers and Treatment Response to Accelerated Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder
Led by Istanbul University - Cerrahpasa · Updated on 2026-05-08
30
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Purpose: This study aims to evaluate the effectiveness of an accelerated intermittent Theta Burst Stimulation (iTBS) protocol-a non-invasive brain stimulation technique-targeted at the dorsomedial prefrontal cortex (dmPFC) and anterior cingulate cortex (ACC) in patients with treatment-resistant Obsessive-Compulsive Disorder (OCD). Additionally, the study seeks to identify electrophysiological biomarkers (such as EEG microstates and heart rate variability) that may predict which patients are most likely to benefit from the treatment. Methodology: The study will include 30 patients aged 18-65 diagnosed with OCD according to DSM-5 criteria who have not responded sufficiently to standard treatments. Participants will undergo an intensive 7-day treatment program consisting of 4 iTBS sessions per day (totaling 28 sessions). Clinical symptoms will be assessed before and after the treatment using standardized scales, including the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A). Resting-state EEG measurements and heart rate data will be recorded during and after the sessions to analyze physiological changes. Goal: The findings are expected to contribute to the development of personalized neuromodulation protocols and help identify predictors of treatment response for OCD patients.
CONDITIONS
Official Title
Electrophysiological Biomarkers and Treatment Response to Accelerated Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 65 years of age
- Diagnosed with Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria
- Not responding sufficiently to at least one adequate dose and duration of Selective Serotonin Reuptake Inhibitor (SSRI) treatment
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score of 20 or higher at initial evaluation
- No changes in current medications in the last 2 months and commitment to maintain stable doses during the study
- Provided informed consent and have no contraindications for Transcranial Magnetic Stimulation (TMS)
You will not qualify if you...
- Severe neurological disorders or neurodegenerative diseases
- Any condition with increased risk of seizures
- History of cochlear implants, metal implants in the head or neck area, cardiac pacemakers, deep brain stimulation, or vagus nerve stimulation
- History of neurosurgical intervention
- General contraindications for Transcranial Magnetic Stimulation therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cerrahpaşa Tıp Fakültesi Prof. Dr. Murat Dilmener Hastanesi
Istanbul, Bakirkoy, Turkey (Türkiye), 34153
Actively Recruiting
Research Team
S
Sarp Yoldas, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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