Study of Brain Activity Markers and Response to Accelerated Brain Stimulation Treatment in Adults With Obsessive-Compulsive Disorder

What this Trial Is About

Researchers are evaluating an accelerated intermittent Theta Burst Stimulation iTBS protocol, a non-invasive brain stimulation method, for patients with treatment-resistant Obsessive-Compulsive Disorder OCD. The study aims to assess the effectiveness of targeting the dorsomedial prefrontal cortex dmPFC and anterior cingulate cortex ACC and to identify electrophysiological biomarkers like EEG microstates and heart rate variability that may predict treatment response. Participants will undergo an intensive 7-day treatment program with 4 iTBS sessions each day, totaling 28 sessions. The stimulation is delivered at 100% of motor threshold using a MagVenture MagPro R30 stimulator with a Cool D-B80 double cone coil, focusing on specific brain regions. Patients will continue their stable dose of Selective Serotonin Reuptake Inhibitors SSRIs during the trial. During the study, clinical symptoms will be measured before and after treatment using scales such as the Yale-Brown Obsessive Compulsive Scale Y-BOCS, Hamilton Depression Rating Scale, and Hamilton Anxiety Rating Scale. Resting-state EEG and heart rate data are recorded during and after sessions to monitor physiological changes. Follow-up assessments occur at 1, 3, and 6 months post-treatment to evaluate symptom changes and treatment effects.

Electrophysiological Biomarkers and Treatment Response to Accelerated Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder