High-density EEG Study of Mild Cognitive Impairment in Parkinsons Disease Exploring Brain Activity and Connectivity in PD with and without Cognitive Changes

What this Trial Is About

Researchers are investigating the brain activity linked to Mild Cognitive Impairment MCI in people with Parkinsons disease PD. The study aims to find connections between difficulties in thinking and movement and brain signals measured by electroencephalography EEG. It involves 42 participants divided into three groups healthy people, those with PD and MCI, and those with PD but no MCI. The study uses brain scans and cognitive tests to understand these changes better. Participants will undergo detailed neuropsychological testing to classify their cognitive status. They will have high-density EEG recordings both while resting and performing cognitive tasks to measure brain activity. Structural magnetic resonance imaging MRI will also be done to combine brain structure data with EEG results, helping to map brain connectivity accurately. During the study, participants will complete cognitive evaluations, frailty assessments, and accuracy tests during tasks. Researchers will analyze brain wave patterns and functional connections in the brain from the EEG and MRI data. The study focuses on how brain connectivity relates to cognitive and motor impairments, aiming to improve future treatments and prevention. The research is observational and includes follow-up at baseline for all measures.

Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation