Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
NCT07166848

Electrostimulation Study for Ocular Graft vs. Host Disease

Led by Zhonghui K. Luo, MD, PhD · Updated on 2025-12-17

15

Participants Needed

1

Research Sites

208 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.

CONDITIONS

Official Title

Electrostimulation Study for Ocular Graft vs. Host Disease

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of chronic ocular graft vs. host disease (oGVHD) confirmed by ICCGVHD criteria (probable or definite)
  • Ocular Surface Disease Index (OSDI) score of 22 or higher
  • NEI corneal staining score (or modified NEI score) of 2 or higher
Not Eligible

You will not qualify if you...

  • Any open wound on the eyelid
  • Active corneal ulcer, dacryocystitis, hordeolum, filamentary keratitis, uveitis, retinal detachment, uncontrolled glaucoma, or other active eye conditions as determined by the investigator
  • Presence of pacemaker or implantable cardioverter defibrillator (ICD)
  • Currently pregnant or potential to be pregnant during the study
  • Ocular surgery (including intravitreal injections) within the past 3 months
  • Systemic surgery within the past 2 months
  • Non-surgical eyelid procedures (e.g., punctal plugs or cautery) within 1 month before study start
  • Use of cytotoxic agents, drugs that inhibit peripheral nerve regeneration (such as Gabapentin or Nicotine), radiation therapy, or other treatments per investigator's discretion
  • Changes in immunosuppression regimen within 1 month before or during the study
  • Use of contact lenses of any kind

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Massachusetts Eye and Ear - Longwood Campus

Boston, Massachusetts, United States, 02215

Actively Recruiting

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Research Team

M

Michael Cheung, MSc, CCRP

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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