Actively Recruiting
Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases
Led by Sun Yat-sen University · Updated on 2025-11-17
130
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to explore the safety and efficacy of eliminating the PTV (planning target volume) margins based on online adaptive stereotactic radiotherapy for patients with early-stage non-small cell lung cancer (NSCLC) or pulmonary oligometastases.
CONDITIONS
Official Title
Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or PET-CT confirmed untreated early-stage non-small cell lung cancer (T1-2N0M0) that is inoperable or if surgery is refused, or PET-CT/chest CT confirmed lung oligometastases (up to 3 metastases, single lesion diameter up to 5 cm)
- Age 18 years or older
- ECOG performance status score of 0 to 2
- Serum hemoglobin level of at least 80 g/L, platelets at least 100,000/µL, and absolute neutrophil count at least 1,500/µL
- Serum creatinine no more than 1.25 times the upper normal limit or creatinine clearance at least 60 ml/min
- Serum bilirubin no more than 1.5 times the upper normal limit, AST and ALT no more than 2.5 times the upper normal limit, alkaline phosphatase no more than 5 times the upper normal limit
- Forced expiratory volume in 1 second (FEV1) at least 0.5 L
- Normal CB6 range
- Patient and family provide informed consent
You will not qualify if you...
- Tumors with bronchial invasion
- Any condition that contraindicates radiotherapy, including active infections, recent myocardial infarction within 6 months, symptomatic heart disease such as unstable angina, congestive heart failure, or uncontrolled arrhythmias
- Pregnant or breastfeeding women, or women without pregnancy testing
- Substance abuse, chronic alcoholism, or AIDS
- Uncontrollable seizures or loss of self-control due to psychiatric disorders
- History of severe allergies or specific sensitivities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
B
Bo Qiu, Professor
CONTACT
H
Hui Liu, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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