Study of Embolization Treatment for Joint Problems in Patients with Hereditary Blood Clotting Disorders

What this Trial Is About

This research aims to study 30 people with hereditary coagulopathies who have joint problems and chronic synovitis caused by bleeding into the elbows, knees, andor ankles. These participants are followed at the Hemophilia Center of the University of Sao Paulos Hospital after ethical approval. The study evaluates these patients over a long period to understand the effects of a specific embolization treatment on their joint health and quality of life. Participants will receive a superselective embolization procedure using spherical microparticles called Embosphere to target arteries in the affected joints. This treatment aims to cause partial blood flow blockage and reduce abnormal synovial tissue enhancement. The study includes imaging tests such as X-rays and magnetic resonance imaging MRI of the affected joints, alongside functional and quality of life assessments. Assessments will be done at the start and then at 1, 3, 6, 12, 24, 36, 48, and 60 months after the embolization procedure. These include measuring synovium thickness, synovitis, muscle strength, balance, fall risk, pain, stiffness, physical function, and quality of life through various scales and questionnaires. This thorough follow-up will help researchers monitor changes and safety over five years.

Embolization in Hereditary Coagulopathies