Actively Recruiting

Phase Not Applicable
Age: 18Years - 70Years
All Genders
NCT04672551

EMDR Treatment in PTSD Following Cardiac Events

Led by University of Zurich · Updated on 2026-05-07

60

Participants Needed

1

Research Sites

366 weeks

Total Duration

On this page

Sponsors

U

University of Zurich

Lead Sponsor

E

EMDR Europe

Collaborating Sponsor

AI-Summary

What this Trial Is About

Cardiac events can often result in debilitating and persistent psychological symptoms. A key question involves whether optimal treatment of cardiac-induced posttraumatic stress disorder (PTSD) reduces PTSD symptoms and thereby may offset the risk of recurrent or worsening cardiovascular disease. Cardiac-induced PTSD 1) is prevalent, 2) features symptoms unique to internal ongoing somatic threat, with fears and worries that can be distinguished from PTSD resulting from external causes, 3) is persistent, 4) is associated with negative physical and emotional consequences, and 5) has not been the subject of randomized-controlled treatment trials (RCT). There is preliminary evidence suggesting that patients with cardiac-disease induced PTSD might particularly profit from EMDR. Nevertheless, this possibility has not been tested in cardiac-induced PTSD. Currently, patients with cardiac-induced PTSD are not routinely offered trauma-focused therapies, with a lack of scientific evidence likely being one major reason for this omission. If our proposed RCT shows that EMDR can be an effective treatment for patients with ACS-induced PTSD, EMDR could be routinely implemented as first-line treatment. The RCT outcomes might inform larger trials to test whether poor prognosis in terms of major adverse cardiovascular events can be improved through EMDR in patients with cardiac-induced PTSD.

CONDITIONS

Official Title

EMDR Treatment in PTSD Following Cardiac Events

Who Can Participate

Age: 18Years - 70Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 70 years
  • Male or female participants
  • Diagnosis of STEMI (ST-elevation myocardial infarction) or non-STEMI (troponin positive) confirmed by a cardiologist at the time of the cardiac event
  • Diagnosis of PTSD caused by the cardiac event
Not Eligible

You will not qualify if you...

  • Diagnosis of psychotic disorder, bipolar disorder, or substance abuse as measured by the Mini International Neuropsychiatric Interview (M.I.N.I)
  • Acute suicidal thoughts as assessed by the M.I.N.I
  • Use of non-selective beta blockers (e.g., propranolol) during the study period
  • Ongoing psychological or psychiatric treatment outside of this trial during the study period
  • Vision problems such as strabismus that prevent adequate eye movement
  • Insufficient knowledge of the German language
  • Expected inability or unwillingness to follow the study protocol
  • Regular use of benzodiazepine medication

AI-Screening

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Trial Site Locations

Total: 1 location

1

University Hospital Zurich

Zurich, Switzerland

Actively Recruiting

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Research Team

C

Christoph Mueller-Pfeiffer, PD Dr. med.

CONTACT

M

Mary Princip, PD Dr. phil.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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