Actively Recruiting
Emergency Medicine Pulmonary Embolism Testing Multicentre Study
Led by Dr. Kerstin de Wit · Updated on 2026-04-20
4000
Participants Needed
4
Research Sites
195 weeks
Total Duration
On this page
Sponsors
D
Dr. Kerstin de Wit
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging. A new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results. The study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.
CONDITIONS
Official Title
Emergency Medicine Pulmonary Embolism Testing Multicentre Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Emergency department patient who is tested by an emergency physician for PE
You will not qualify if you...
- Patient is younger than 18 years of age
- No documentation of whether PE is the most likely diagnosis
- D-dimer is not tested or not resulted during the emergency visit
- D-dimer level is known before documentation of whether PE is the most likely diagnosis
- D-dimer is ordered before the physician assesses the patient
- Patient has opted out of all research at the participating site
- Patient leaves against medical advice
- Patient had PE or deep vein thrombosis imaging within the prior 30 days
- There is a new non-PE reason for anticoagulation
- Patient started treatment for presumed PE before PE testing
- Patient was previously enrolled in the study
- Patient has prior lower extremity deep vein thrombosis without baseline ultrasound
- Patient was transferred from another hospital
- Patient does not reside in Ontario
- Patient has no valid Ontario Health Insurance Plan card
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Hamilton Health Sciences Corporation
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
2
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
3
London Health Sciences Centre Research Inc
London, Ontario, Canada
Active, Not Recruiting
4
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1Y 4E9
Active, Not Recruiting
Research Team
N
Natasha S Clayton
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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