Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest

What this Trial Is About

Researchers are evaluating the feasibility of using pre-hospital resuscitative endovascular balloon occlusion of the aorta (REBOA) alongside conventional Advanced Life Support (ALS) in adults who suffer non-traumatic out-of-hospital cardiac arrest (OHCA). The study aims to understand the technical feasibility of performing REBOA during resuscitation and to document its physiological effects, such as improving blood flow to the heart and brain. This early-stage study follows the IDEAL framework for surgical interventions and intends to inform future larger trials. The study involves delivering the ER-REBOA catheter to achieve rapid aortic occlusion during resuscitation for patients who are refractory to conventional ALS. The procedure will be performed by experienced physicians as part of a structured training program. Up to twenty patients aged 18 to 80 years will be enrolled, all treated by a specialized air ambulance REBOA team within the East of England area. The intervention will be done during ongoing resuscitation efforts at the scene. Participants will be closely monitored for device delivery and procedural timing within one hour of initiation. Researchers will assess haemodynamic and oxygenation responses, including near-infrared spectroscopy and end-tidal carbon dioxide measures, to evaluate the physiological impact of REBOA. Safety and any complications will be recorded, and data will help determine if this technique is ready for larger randomized studies. The total participation duration is limited to the immediate resuscitation period and related assessments.

Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest