Actively Recruiting
Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest
Led by Queen Mary University of London · Updated on 2026-03-02
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
Q
Queen Mary University of London
Lead Sponsor
E
East Anglian Air Ambulance
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the feasibility of using pre-hospital resuscitative endovascular balloon occlusion of the aorta REBOA alongside conventional Advanced Life Support ALS in adults who suffer non-traumatic out-of-hospital cardiac arrest OHCA. The study aims to understand the technical feasibility of performing REBOA during resuscitation and to document its physiological effects, such as improving blood flow to the heart and brain. This early-stage study follows the IDEAL framework for surgical interventions and intends to inform future larger trials. The study involves delivering the ER-REBOA catheter to achieve rapid aortic occlusion during resuscitation for patients who are refractory to conventional ALS. The procedure will be performed by experienced physicians as part of a structured training program. Up to twenty patients aged 18 to 80 years will be enrolled, all treated by a specialized air ambulance REBOA team within the East of England area. The intervention will be done during ongoing resuscitation efforts at the scene. Participants will be closely monitored for device delivery and procedural timing within one hour of initiation. Researchers will assess haemodynamic and oxygenation responses, including near-infrared spectroscopy and end-tidal carbon dioxide measures, to evaluate the physiological impact of REBOA. Safety and any complications will be recorded, and data will help determine if this technique is ready for larger randomized studies. The total participation duration is limited to the immediate resuscitation period and related assessments.
CONDITIONS
Brief Title
Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-traumatic out-of-hospital cardiac arrest within the East of England area with East Anglian Air Ambulance REBOA team attendance
- Age 18 to 80 years according to available information or estimate at the scene
- No-flow time less than 10 minutes (time without CPR)
- In cardiac arrest with no sustained return of spontaneous circulation upon arrival of the REBOA team
You will not qualify if you...
- Age below 18 or above 80 years
- Known terminal illness
- Multiple severe co-morbidities
- Traumatic cardiac arrest
- Inability to deploy mechanical CPR such as the LUCAS device
- Pregnancy, obvious or suspected
Research Team
P
Paul Rees, MD(Res)
K
Kate Lachowycz, PhD
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here