Actively Recruiting
The EMINENCE Study - PET/MR Imaging of Head Neck Cancer
Led by Norwegian University of Science and Technology · Updated on 2026-04-14
390
Participants Needed
2
Research Sites
411 weeks
Total Duration
On this page
Sponsors
N
Norwegian University of Science and Technology
Lead Sponsor
S
St. Olavs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Head and neck cancers (HNC) often receive radiotherapy as part of their treatment. However, unacceptable failure rates and severe side effects remain a challenge. The improvements in radiotherapy are closely related to improvements in medical imaging. Functional imaging, where intratumoural characteristics such as tumour oxygenation, metabolism, and blood vessel function can be quantified, offers possibilities to personalize the radiotherapy. In this study we will establish the clinical workflow for PET- and MRI-based radiotherapy in HNC by acquiring images prior to and during radiotherapy to develop new concepts for image-based biologically adaptive radiotherapy, both based on photon-based radiotherapy and also proton therapy, which soon will be available for cancer patients in Norway. The investigators aim to contribute towards further developments of personalised high-precision radiotherapy for HNC patients resulting in improved outcome, reduced side-effects and better quality of life.
CONDITIONS
Official Title
The EMINENCE Study - PET/MR Imaging of Head Neck Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give full written consent according to approved protocol
- Histologically confirmed squamous cell carcinoma in the head and neck region (pharynx, larynx, oral cavity or sinonasal area)
- Locally advanced disease without signs of spread (T3/T4 and/or N1-3, M0) on diagnostic imaging
- Scheduled for definitive radiotherapy with curative intent, with or without chemotherapy
- Adequate kidney function with creatinine clearance at least 60 ml/minute
- Lymph node metastasis from unknown primary cancer in upper neck (level II-III) with negative PET/CT outside head-neck region may be included at investigator discretion
You will not qualify if you...
- General contraindications for MRI such as pacemaker, aneurysm clips, metal in the body, or severe claustrophobia
- Serious other illnesses, including prior or other cancers, that may interfere with study completion or evaluation (e.g. poorly controlled diabetes)
- Histologically confirmed squamous cell carcinoma of the same or other origin within the last five years
- Patient chooses to withdraw from the study at any time
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University Hospital of North Norway
Tromsø, Norway
Not Yet Recruiting
2
St Olavs Hospital, Department of Oncology
Trondheim, Norway
Actively Recruiting
Research Team
M
Miriam Alsaker, phd
CONTACT
K
Kathrine Røe Redalen, phd
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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