Actively Recruiting
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Led by Wake Forest University Health Sciences · Updated on 2026-02-12
600
Participants Needed
2
Research Sites
258 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
U
University of Chicago
Collaborating Sponsor
AI-Summary
What this Trial Is About
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore, it is not well understood how to design optimal incentives to treat opioid abuse. This project will conduct a randomized evaluation of two types of dynamically adjusting incentive schedules for people with opioid use disorders or cocaine use disorders: "escalating" schedules where incentive amounts increase with success to increase incentive power, and "de-escalating" schedules where incentive amounts decrease with success to improve incentive targeting. Both schemes are implemented with a novel "turnkey" mobile application, making them uniquely low-cost, low-hassle, and scalable. Effects will be measured on abstinence outcomes, including longest duration of abstinence and the percentage of negative drug tests. In combination with survey data, variation from the experiment will shed light on the barriers to abstinence more broadly and inform the understanding of optimal incentive design.
CONDITIONS
Official Title
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 18 years old
- Meet DSM-5 criteria for opioid, cocaine, or methamphetamine use disorder as shown by relevant clinical codes or notes
- Have a smartphone with data plan and willing to download the DynamiCare app
- Have an email address accessible from the smartphone
- Currently in residential, day, partial day, or outpatient substance use treatment
- Likely to benefit from contingency management by either starting treatment within the last 14 days or using non-medical opioids, cocaine, or methamphetamine within the last 21 days
- Understand English
You will not qualify if you...
- Evidence of active non-substance related psychosis that could impair participation as determined by the study doctor
- Significant cognitive impairment or having a legal guardian due to cognitive impairment as determined by the study doctor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Rogers Behavioral Health
Oconomowoc, Wisconsin, United States, 53066
Actively Recruiting
2
Advocate Aurora Behavioral Health Services
Wauwatosa, Wisconsin, United States, 53212
Actively Recruiting
Research Team
K
Kevin Petranu
CONTACT
M
Mercedes Robaina, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
7
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