Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT04927143

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Led by Wake Forest University Health Sciences · Updated on 2026-02-12

600

Participants Needed

2

Research Sites

258 weeks

Total Duration

On this page

Sponsors

W

Wake Forest University Health Sciences

Lead Sponsor

U

University of Chicago

Collaborating Sponsor

AI-Summary

What this Trial Is About

Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore, it is not well understood how to design optimal incentives to treat opioid abuse. This project will conduct a randomized evaluation of two types of dynamically adjusting incentive schedules for people with opioid use disorders or cocaine use disorders: "escalating" schedules where incentive amounts increase with success to increase incentive power, and "de-escalating" schedules where incentive amounts decrease with success to improve incentive targeting. Both schemes are implemented with a novel "turnkey" mobile application, making them uniquely low-cost, low-hassle, and scalable. Effects will be measured on abstinence outcomes, including longest duration of abstinence and the percentage of negative drug tests. In combination with survey data, variation from the experiment will shed light on the barriers to abstinence more broadly and inform the understanding of optimal incentive design.

CONDITIONS

Official Title

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age at least 18 years old
  • Meet DSM-5 criteria for opioid, cocaine, or methamphetamine use disorder as shown by relevant clinical codes or notes
  • Have a smartphone with data plan and willing to download the DynamiCare app
  • Have an email address accessible from the smartphone
  • Currently in residential, day, partial day, or outpatient substance use treatment
  • Likely to benefit from contingency management by either starting treatment within the last 14 days or using non-medical opioids, cocaine, or methamphetamine within the last 21 days
  • Understand English
Not Eligible

You will not qualify if you...

  • Evidence of active non-substance related psychosis that could impair participation as determined by the study doctor
  • Significant cognitive impairment or having a legal guardian due to cognitive impairment as determined by the study doctor

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 2 locations

1

Rogers Behavioral Health

Oconomowoc, Wisconsin, United States, 53066

Actively Recruiting

2

Advocate Aurora Behavioral Health Services

Wauwatosa, Wisconsin, United States, 53212

Actively Recruiting

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Research Team

K

Kevin Petranu

CONTACT

M

Mercedes Robaina, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

7

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