Actively Recruiting
End-Tidal Oxygen for Intubation in the Emergency Department
Led by Sydney Local Health District · Updated on 2024-09-19
1400
Participants Needed
9
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation. For many years anaesthetists have used end-tidal oxygen (ETO2) levels to guide the effectiveness of preoxygenation prior to intubation. The ETO2 gives an objective measurement of preoxygenation efficacy. This is currently not available in most EDs. This trial evaluates the use of ETO2 on the rate of hypoxia during intubation for patients in the ED.
CONDITIONS
Official Title
End-Tidal Oxygen for Intubation in the Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The patient is located in the ED resuscitation bay of the participating centre.
- The planned procedure is orotracheal intubation using a laryngoscope and RSI technique with preoxygenation for patients who are spontaneously breathing.
- The patient is deemed to be at high risk of hypoxia during RSI by the treating ED clinician, including:
- Patients requiring any form of oxygen therapy before preoxygenation.
- Patients with respiratory pathology such as pneumonia, pulmonary oedema, ARDS, aspiration, pulmonary contusion, infective exacerbations of lung disease, or pulmonary embolism.
- Patients with high oxygen consumption conditions such as sepsis, diabetic ketoacidosis, alcohol or drug withdrawal, seizures, or thyrotoxicosis.
- Patients with underlying conditions predisposing to hypoxemia such as obesity, pregnancy, lung disease, or severe injury like hypovolaemia or haemorrhage.
- Any other patients the treating clinician considers at high risk for hypoxemia during RSI.
You will not qualify if you...
- Patient is known to be less than 18 years old.
- Patient has a supraglottic device in place such as iGel or LMA.
- Patient is known to be pregnant.
- Patient is known to be a prisoner.
- Patient was intubated before arrival in the hospital (prehospital intubation).
- Immediate need for tracheal intubation precludes preoxygenation, such as during cardiac arrest.
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Trial Site Locations
Total: 9 locations
1
Hennepin Medical Center
Minneapolis, Minnesota, United States, 55451
Not Yet Recruiting
2
University of New Mexico Medical Center
Albuquerque, New Mexico, United States, 87106
Not Yet Recruiting
3
Lincoln Medical Center
The Bronx, New York, United States, 10451
Actively Recruiting
4
Westmead Hospital
Sydney, New South Wales, Australia, 2000
Not Yet Recruiting
5
Royal Prince Alfred Hospital
Sydney, New South Wales, Australia, 2050
Actively Recruiting
6
Liverpool Hospital
Sydney, New South Wales, Australia
Not Yet Recruiting
7
Northern Beaches Hospital
Sydney, New South Wales, Australia
Actively Recruiting
8
Royal North Shore Hospital
Sydney, New South Wales, Australia
Not Yet Recruiting
9
The Alfred Hospital
Melbourne, Victoria, Australia
Not Yet Recruiting
Research Team
M
Matthew Oliver, MBBS
CONTACT
N
Naomi Derrick
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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