Actively Recruiting
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Led by Centre Hospitalier St Anne · Updated on 2025-07-24
600
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier St Anne
Lead Sponsor
D
Direction Générale de l'Offre de Soins
Collaborating Sponsor
AI-Summary
What this Trial Is About
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks. Randomized clinical trials (RCTs) have demonstrated the benefits of carotid endarterectomy (CEA) in reducing stroke risk in patients with severe symptomatic carotid stenosis. Carotid artery stenting (CAS) has been developed as an alternative to CEA, offering several potential advantages, such as avoiding local surgical complications. However, unlike CEA, CAS has not been compared to medical therapy in RCTs for symptomatic carotid stenosis.
CONDITIONS
Official Title
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient age 18 years or over
- Hemispheric or retinal transient ischemic attack or a non-disabling stroke (or retinal infarct) within 15 days before enrollment
- Stenosis of 50% to 99% in the symptomatic carotid artery (NASCET method) with revascularization planned according to guidelines
You will not qualify if you...
- Patients unwilling or unable to participate in follow-up
- Preexisting disability with Modified Rankin Score of 3 or higher
- Nonatherosclerotic carotid disease
- Severe tandem lesions
- Previous revascularization of the symptomatic carotid stenosis
- History of bleeding disorder
- Unstable angina
- Contraindication to dual antiplatelet therapy
- Contraindication to MRI
- Life expectancy less than 2 years
- Percutaneous or surgical intervention within 30 days before or after the study procedure
- Stenotic lesion not relevant in arterial workup selection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre hospitalier Sainte-Anne
Paris, France, 75014
Actively Recruiting
Research Team
D
David Calvet, Professor
CONTACT
D
DRCI DRCI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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