Actively Recruiting
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)
Led by University Health Network, Toronto · Updated on 2026-05-04
150
Participants Needed
1
Research Sites
773 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It is reported that more than 90,000 patients died of lung cancer and more than 20% of them were older than 80 years in North America. Therefore a less invasive but effective treatment is required for patients with lung cancer of advanced age, diminished pulmonary functions, and chronic diseases. Stereotactic body radiation therapy (SBRT) is an effective and well-tolerated treatment for early stage lung cancer in medically inoperable patients. On the other hand, accurate mediastinal and hilar lymph node staging is one of the most important factors that determine the outcome and indications for SBRT. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a novel, minimally invasive modality that enables the assessment of mediastinal and hilar lymph nodes with a high sensitivity. Accurate lymph node staging by EBUS-TBNA will allow opportunities for high-risk patients with lung cancer to undergo minimally invasive treatment.
CONDITIONS
Official Title
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Confirmed lung cancer requiring EBUS-TBNA for mediastinal and hilar staging before SBRT
- Performance status (WHO/ECOG) score of 0 to 2
- Cytological or histological confirmation of non-small cell lung cancer
- Stage T1-2 disease with no distant metastasis
- Screening by computed tomography (CT) and positron emission tomography (PET)
- Medically inoperable for surgery
- Patients who have refused surgery
You will not qualify if you...
- Not medically fit for bronchoscopy based on clinical judgment
- Active systemic, lung, or pericardial infection
- Pregnant or breastfeeding women
- Planned treatment with conventional radiotherapy, chemotherapy, biological therapy, vaccine therapy, or surgery except if disease progresses
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto General Hospital
Toronto, Ontario, Canada, M5G 1L7
Actively Recruiting
Research Team
J
Judy McConnell
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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