Actively Recruiting
Endocrine Therapy-Induced Alopecia in Postmenopausal and Premenopausal Female Breast Cancer Patients
Led by Mayo Clinic · Updated on 2026-04-30
170
Participants Needed
23
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluates endocrine therapy-induced alopecia among postmenopausal and premenopausal female patients with breast cancer. Alopecia is one of the most feared side effects of cancer-directed therapy, causing distress in women starting treatment for breast cancer. While alopecia is a well-known side effect of many chemotherapy drugs, it has also been reported by women undergoing endocrine therapy. Despite the frequent reports of alopecia related to endocrine therapy, hair loss is rarely reported as a side effect of endocrine therapy and the exact characterization of alopecia is not well understood. By having postmenopausal and premenopausal breast cancer patients describe their hair loss symptoms experienced while undergoing endocrine therapy, researchers may be able to better characterize the incidence, timing, duration, and severity of alopecia and whether the different types of endocrine therapy cause more or less trouble in this regard.
CONDITIONS
Official Title
Endocrine Therapy-Induced Alopecia in Postmenopausal and Premenopausal Female Breast Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �318 years
- Female patients diagnosed with breast cancer treated with curative intent, except those receiving CDK4/6 inhibitors who may have more advanced disease
- Able to provide informed consent
- Able to complete questionnaires independently or with help
- Belong to one of the five study groups, each with an accrual goal of 30 patients
- Willing to complete questionnaires every 3 months
- Able to complete the first questionnaire within 2 weeks of starting therapy (tamoxifen, aromatase inhibitor, or CDK4/6 inhibitor)
You will not qualify if you...
- Baseline hair loss rated 2 or higher on a 0-10 scale
- Planned chemotherapy or other cancer-directed therapy concurrently (except CDK4/6 inhibitor in cohort 3)
- Previous use of endocrine therapy for breast cancer
- Received chemotherapy within the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 23 locations
1
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States, 56007
Actively Recruiting
2
Essentia Health Baxter Clinic
Baxter, Minnesota, United States, 56425
Actively Recruiting
3
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States, 56601
Actively Recruiting
4
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, United States, 56401
Actively Recruiting
5
Essentia Health - Deer River Clinic
Deer River, Minnesota, United States, 56636
Actively Recruiting
6
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, United States, 56501
Actively Recruiting
7
Essentia Health Cancer Center
Duluth, Minnesota, United States, 55805
Actively Recruiting
8
Essentia Health Ely Clinic
Ely, Minnesota, United States, 55731
Actively Recruiting
9
Essentia Health - Fosston
Fosston, Minnesota, United States, 56542
Actively Recruiting
10
Fairview Grand Itasca Clinic & Hospital
Grand Rapids, Minnesota, United States, 55744
Actively Recruiting
11
Essentia Health Hibbing Clinic
Hibbing, Minnesota, United States, 55746
Actively Recruiting
12
Fairview Range Medical Center
Hibbing, Minnesota, United States, 55746
Actively Recruiting
13
Essentia Health - International Falls Clinic
International Falls, Minnesota, United States, 56649
Actively Recruiting
14
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States, 56001
Actively Recruiting
15
MMCORC CentraCare Monticello Cancer Center
Monticello, Minnesota, United States, 55362
Active, Not Recruiting
16
Essentia Health Moose Lake
Moose Lake, Minnesota, United States, 55767
Actively Recruiting
17
Essentia Health - Park Rapids
Park Rapids, Minnesota, United States, 56470
Actively Recruiting
18
Fairview Northland Medical Center
Princeton, Minnesota, United States, 55731
Actively Recruiting
19
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
20
Essentia Health Sandstone
Sandstone, Minnesota, United States, 55072
Actively Recruiting
21
Sanford Health Thief River Falls
Thief River Falls, Minnesota, United States, 56701
Actively Recruiting
22
Essentia Health Virginia Clinic
Virginia, Minnesota, United States, 55792
Actively Recruiting
23
Sanford Health Worthington
Worthington, Minnesota, United States, 56187
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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