Actively Recruiting
Endocrine Therapy-Induced Alopecia Natural History Evaluation Among Female Breast Cancer Survivors
Led by Mayo Clinic · Updated on 2026-04-30
170
Participants Needed
23
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying hair loss caused by endocrine therapy in both postmenopausal and premenopausal women with breast cancer. Hair loss is a common and distressing side effect of cancer treatments, and this study aims to better understand how often it occurs, its timing, duration, and severity, especially related to different types of endocrine therapies. The study compares women receiving tamoxifen, aromatase inhibitors, aromatase inhibitors with CDK4/6 inhibitors, and those not receiving endocrine therapy. This observational study involves patients completing questionnaires and surveys about their hair loss. Medical records will also be reviewed to gather information. The study includes four main groups of postmenopausal women and a premenopausal group that has already completed enrollment. Participants answer questions every three months, starting within two weeks of beginning endocrine therapy or CDK4/6 inhibitor treatment. Participants will provide detailed reports about their hair loss symptoms and complete regular surveys to measure the impact on quality of life. Researchers will analyze patient-reported data on hair loss incidence and severity up to two years. The study helps characterize treatment-related alopecia and its effects, supporting better understanding of this side effect during breast cancer therapy.
CONDITIONS
Brief Title
Endocrine Therapy-Induced Alopecia in Postmenopausal and Premenopausal Female Breast Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 years or older
- Diagnosis of breast cancer treated with curative intent, except for those receiving CDK4/6 inhibitors who may have more advanced disease
- Ability to provide informed consent
- Ability to complete questionnaires independently or with assistance
- Willingness to complete questionnaires every 3 months
- Ability to complete the first questionnaire within 2 weeks of starting endocrine therapy or CDK4/6 inhibitor
- Enrollment in one of the five study groups (noting that groups close after reaching 30 patients)
You will not qualify if you...
- Baseline hair loss rated 2 or higher on a 0 to 10 scale
- Planned receipt of chemotherapy or other cancer-directed therapies concurrently, except CDK4/6 inhibitors
- Prior use of endocrine therapy for breast cancer
- Receipt of chemotherapy within the previous 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) to confirm eligibility and complete consent
Duration - Up to 2 years
Participants complete alopecia questionnaires and surveys every 3 months and have their medical records reviewed to evaluate hair loss related to endocrine therapy.
Quarterly visits or remote assessments every 3 months
Trial Site Locations
Total: 23 locations
1
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States, 56007
Actively Recruiting
2
Essentia Health Baxter Clinic
Baxter, Minnesota, United States, 56425
Actively Recruiting
3
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States, 56601
Actively Recruiting
4
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, United States, 56401
Actively Recruiting
5
Essentia Health - Deer River Clinic
Deer River, Minnesota, United States, 56636
Actively Recruiting
6
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, United States, 56501
Actively Recruiting
7
Essentia Health Cancer Center
Duluth, Minnesota, United States, 55805
Actively Recruiting
8
Essentia Health Ely Clinic
Ely, Minnesota, United States, 55731
Actively Recruiting
9
Essentia Health - Fosston
Fosston, Minnesota, United States, 56542
Actively Recruiting
10
Fairview Grand Itasca Clinic & Hospital
Grand Rapids, Minnesota, United States, 55744
Actively Recruiting
11
Essentia Health Hibbing Clinic
Hibbing, Minnesota, United States, 55746
Actively Recruiting
12
Fairview Range Medical Center
Hibbing, Minnesota, United States, 55746
Actively Recruiting
13
Essentia Health - International Falls Clinic
International Falls, Minnesota, United States, 56649
Actively Recruiting
14
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States, 56001
Actively Recruiting
15
MMCORC CentraCare Monticello Cancer Center
Monticello, Minnesota, United States, 55362
Active, Not Recruiting
16
Essentia Health Moose Lake
Moose Lake, Minnesota, United States, 55767
Actively Recruiting
17
Essentia Health - Park Rapids
Park Rapids, Minnesota, United States, 56470
Actively Recruiting
18
Fairview Northland Medical Center
Princeton, Minnesota, United States, 55731
Actively Recruiting
19
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
20
Essentia Health Sandstone
Sandstone, Minnesota, United States, 55072
Actively Recruiting
21
Sanford Health Thief River Falls
Thief River Falls, Minnesota, United States, 56701
Actively Recruiting
22
Essentia Health Virginia Clinic
Virginia, Minnesota, United States, 55792
Actively Recruiting
23
Sanford Health Worthington
Worthington, Minnesota, United States, 56187
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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