Study on Changes in Endometrial Immune Profile and IVF Outcomes After Autologous Intrauterine Platelet Rich Plasma Treatment

What this Trial Is About

Researchers are investigating how autologous intrauterine platelet rich plasma PRP treatment affects the endometrial immune profile, endometrial thickness, hormone levels, and IVF outcomes in women undergoing assisted reproduction. The study focuses on women with infertility who have regular menstrual cycles and are receiving embryo transfers. It aims to understand how changes in immune cells within the endometrium may influence IVF success. Participants will receive PRP prepared from their own blood, which will be administered into the uterus by catheter shortly after the LH peak. The PRP administration involves a 1.5 ml dose delivered on day 2 after the LH peak, followed by a short recovery observation before discharge. This treatment is being evaluated for its effect on immune cell populations and hormone levels during the mid-luteal phase. During the study, researchers will measure endometrial immune cells T cells, NK cells, macrophages before and one month after PRP treatment. They will also assess endometrial thickness by ultrasound, blood levels of estradiol and progesterone, and track IVF outcomes including biochemical pregnancy up to 10 weeks and clinical pregnancy confirmed by ultrasound at 12 weeks. Participants will be monitored closely following treatment to evaluate these outcomes.

Endometrial Immune Profile Changes After Autologous Intrauterine PRP Treatment