Studying Inflammation and Cardiovascular Risks in Women with Endometriosis Testing Salsalate Treatment Effects on Vascular Health

What this Trial Is About

Researchers are studying the connection between endometriosis and a higher risk of cardiovascular disease in women. This study aims to understand the underlying mechanisms, focusing on inflammation and the role of the lectin-like oxidized LDL receptor LOX-1 in causing blood vessel dysfunction. The research explores how systemic inflammation from endometriosis may contribute to heart and blood vessel problems in affected women. Participants will receive either 3000 mg per day of salsalate, taken as 1500 mg twice daily for 5 days, or a placebo capsule with microcrystalline cellulose twice daily for 5 days. This study uses a randomized, crossover design, meaning participants will receive both treatments at different times. Salsalate is studied for its potential to reduce inflammation by blocking a key inflammatory pathway. During the study, participants will be monitored through various assessments including measurements of blood flow and blood vessel diameter, protein expression related to LOX-1 in blood and tissue samples, and analysis of reproductive hormones and inflammatory markers. These evaluations occur 5 days after treatment. The trial includes healthy women and women with endometriosis between 18 and 45 years old. Safety and response to treatment will be closely followed throughout the study period, which is expected to complete by the end of 2026.

Endometriosis and Microvascular Dysfunction: Role of Inflammation