Actively Recruiting
Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
Led by University Hospital, Basel, Switzerland · Updated on 2025-02-03
150
Participants Needed
1
Research Sites
180 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal pressure hydrocephalus in terms of clinical improvement.
CONDITIONS
Official Title
Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 40 years of age
- Symptoms lasting at least 3 months but less than 24 months
- No history of head trauma, brain hemorrhage, meningitis, or other secondary hydrocephalus causes
- Must have gait or balance disturbance plus cognitive impairment and/or urinary problems
- Ventricular enlargement (Evans Index > 0.3) not due to brain atrophy or congenital enlargement
- No visible blockage of cerebrospinal fluid flow
- Opening pressure less than 24 cmH2O when lying on the side
- Clinical improvement in at least one main symptom after removing 40-50 ml of cerebrospinal fluid
You will not qualify if you...
- Age 40 years or younger
- No informed consent provided
- Other neurological, psychiatric, or general medical condition explaining symptoms
- Previous brain surgery
- Other types of dementia
- Unable to walk
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Neurosurgery, University Hospital of Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
F
Florian Marc Ebel, Dr. med.
CONTACT
R
Raphael Guzman, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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