Actively Recruiting
Endoscopic Ultrasound (EUS) Intratumoral Injection of CAR-NK Cells in the Treatment of Advanced Pancreatic Cancer
Led by Zhejiang University · Updated on 2024-12-27
20
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, single-arm, open-label, dose-escalation clinical study to evaluate the safety and anti-tumor efficacy of intratumoral NKG2D CAR-NK cell injection guided by endoscopic ultrasound in the treatment of locally advanced pancreatic cancer.
CONDITIONS
Official Title
Endoscopic Ultrasound (EUS) Intratumoral Injection of CAR-NK Cells in the Treatment of Advanced Pancreatic Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years, male or female
- Histologically or cytologically confirmed pancreatic ductal adenocarcinoma or IPMN carcinogenesis
- Recurrent or unresectable locally advanced pancreatic cancer, including patients unable or unwilling to undergo surgery
- ECOG performance status score of 0-1
- Life expectancy of at least 3 months at screening
- Adequate organ and bone marrow function with specified blood test values within stable ranges
- Not pregnant and willing to use effective contraception if of childbearing potential
- Signed informed consent form
- Willing and able to comply with treatment, tests, follow-up, and study requirements
You will not qualify if you...
- Pregnant or breastfeeding females
- Received any anti-tumor therapy for pancreatic cancer within 28 days before enrollment
- Conditions making endoscopic ultrasound injection too risky, including difficult prior procedures, collateral vessels, varicose veins near tumor
- History of other malignancies within 5 years except certain skin and cervical cancers
- Any other health condition that would prevent safe participation as judged by investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
the first affiliated hospital of Zhejiang University，school of medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
Research Team
Q
Qi Zhang, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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