Actively Recruiting
Endoscopic Ultrasound-guided Rendezvous Versus Precut Papillotomy
Led by Chinese University of Hong Kong · Updated on 2026-02-19
188
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
Sponsors
C
Chinese University of Hong Kong
Lead Sponsor
T
Tokyo University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Selective bile duct cannulation is the most important step in endoscopic retrograde cholangiopancreatography (ERCP) for treatment of benign and malignant pancreatobiliary diseases, but it may fail in up to 15% of cases. Precut papillotomy is an advanced ERCP cannulation technique recommended by guidelines for rescue of difficult biliary access, but it is not without limitations. Endoscopic ultrasound (EUS)-guided biliary drainage is a novel interventional EUS technique that has been increasingly performed after failed biliary access by advanced ERCP cannulation techniques.
CONDITIONS
Official Title
Endoscopic Ultrasound-guided Rendezvous Versus Precut Papillotomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients age 18 years or older undergoing ERCP with indication for bile duct cannulation
- Native major papilla
- Difficult bile duct cannulation defined by at least one of: unsuccessful bile duct cannulation within 10 attempts, unsuccessful cannulation within 10 minutes, or two unintended pancreatic duct cannulations or opacifications
- Written informed consent provided
You will not qualify if you...
- Unable to provide written informed consent
- Contraindications for endoscopy due to other health conditions
- Previous biliary sphincterotomy
- Surgically altered upper gastrointestinal anatomy or duodenal obstruction preventing standard ERCP
- Uncorrectable blood clotting problems (INR > 1.5) or low platelets (< 50,000) despite treatment
- Pregnant patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital, The Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Actively Recruiting
Research Team
F
Felix Sia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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