Actively Recruiting
Endothelial Dysfunction After SCI
Led by Craig Hospital · Updated on 2025-11-14
40
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
C
Craig Hospital
Lead Sponsor
U
University of Colorado, Boulder
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.
CONDITIONS
Official Title
Endothelial Dysfunction After SCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over age 18 years
- Chronic spinal cord injury for more than 12 months
- Motor complete spinal cord injury (AIS A or B)
- Paraplegia with neurological level of injury at T2 or below
- Adults over age 18 years without spinal cord injury (for comparison group)
You will not qualify if you...
- Presence of overt chronic diseases based on medical history, physical exam, blood pressure, ECG, and blood tests
- Active infection
- Surgery within the past 3 months
- Current smoking within the past 12 months
- More than low-risk alcohol consumption
- History of drug abuse
- Use of cardiovascular medications or other drugs that could affect study outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Craig Hospital
Englewood, Colorado, United States, 80113
Actively Recruiting
Research Team
G
Genevieve Madera, BS
CONTACT
C
Clare Morey, SLP-CCC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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