Actively Recruiting
Do Endotypes Predict Response and Sequelae in OSA Patients
Led by University of California, San Diego · Updated on 2024-10-02
200
Participants Needed
1
Research Sites
334 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.
CONDITIONS
Official Title
Do Endotypes Predict Response and Sequelae in OSA Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 21-65 years old
- Men and women with a physician diagnosis of obstructive sleep apnea or strongly suspected to have sleep apnea
- Body mass index (BMI) between 20 and 35 kg/m2
You will not qualify if you...
- Current or planned pregnancy
- Nursing
- Unable to provide self-consent or complete English questionnaires
- Already on effective therapy and adherent to treatment for OSA
- Other untreated sleep disorders like periodic limb movement disorder or narcolepsy
- Circadian rhythm disorder
- Unrevascularized coronary artery disease, angina, prior heart attack or stroke, congestive heart failure
- Uncontrolled hypertension (systolic >160, diastolic >95)
- Chronic lung disease requiring supplemental oxygen or with hypercapnia
- Presence of tracheostomy
- Hospitalization within the past 90 days
- Prior peptic ulcer disease, esophageal varices, or gastrointestinal bleeding within 5 years
- Prior gastric bypass surgery
- Chronic liver disease or end-stage kidney disease
- Active cancer
- Allergy to any study drug
- Regular use of breathing-affecting medications (opioids, sedatives/hypnotics including benzodiazepines, theophylline)
- Chronic use of eszopiclone
- Active illicit substance use
- Alcohol use exceeding 1 drink/night for women or 2 drinks/night for men
- Active smoking or vaping within past 6 months
- Psychiatric disease other than controlled depression or anxiety
- Prisoners
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Altman Clinical and Translational Research Institute Building
La Jolla, California, United States, 92037
Actively Recruiting
Research Team
P
Pamela DeYoung
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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