Actively Recruiting
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Led by First Affiliated Hospital of Wannan Medical College · Updated on 2026-04-30
264
Participants Needed
1
Research Sites
216 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability. Radiologically proven a large vessel occlusion (LVO) in patients with minor stroke is a well-established predictor of poor outcomes, while the poor outcomes following best medical management in patients with minor stroke with the underlying presence of a LVO are mainly driven by the occurrence of early neurological deterioration (END). Considering the well-known strong association between lack of arterial recanalization and END, endovascular therapy (EVT) appears as an attractive option to improve functional outcomes for LVO-related patients with stroke with mild symptoms. Whether EVT is safe and effective in patients with mild stroke with an LVO is currently debated, since these patients were typically excluded from the pivotal EVT trials. The current study aimed to further test the hypothesis that endovascular therapy would be superior to medical management with respect to functional recovery among low NIHSS patients caused by acute large-vessel occlusion in the anterior circulation.
CONDITIONS
Official Title
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Time from stroke onset to arterial puncture within 24 hours
- Low NIHSS score between 2 and 5 points with at least one of the following: altered mental status, facial weakness (score 21 1), limb weakness (score 21 1), language disturbance (score 21 1), or hemispatial neglect (score 21 1)
- Confirmed occlusion in intracranial internal carotid artery, proximal M1 or M2 segment of middle cerebral artery by cerebral CTA, MRA, or DSA
- Perfusion imaging showing volume of perfusion delay (Tmax >6 seconds) 21 50 mL
- Written informed consent obtained with agreement for long-term follow-up
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College
Wuhu, Anhui, China, 241000
Actively Recruiting
Research Team
Z
Zhiming Zhou, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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