Actively Recruiting
Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD
Led by The University of Texas Health Science Center at San Antonio · Updated on 2026-03-31
16
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to determine the effects of aerobic exercise as a primer to add-on virtual reality (VR)-based rehabilitation on balance, postural control and neuroplasticity (ability of brain to adapt in structure and function) in individuals with Parkinson's disease (PD). This study will utilize two groups - one group will receive the exercise and VR, while the other group will receive stretching exercise and VR over eight weeks. The study team will administer outcomes at baseline, post-intervention (8 weeks) and follow-up (6 weeks after post-assessment).
CONDITIONS
Official Title
Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of idiopathic Parkinson's disease between ages 18 and 85, at Hoehn and Yahr stages 2 to 3
- Mini Mental State Examination score of 23 or higher
- Mini Balance Evaluations Systems Test (miniBESTest) score of 21.5 or lower
You will not qualify if you...
- History of other neurological diseases like stroke or multiple sclerosis
- History of severe heart or lung disease, uncontrolled high blood pressure, orthostatic hypotension, uncontrolled diabetes, severe osteoporosis, or severe arthritis affecting lower joints
- History of Parkinson's disease-related surgeries such as deep brain stimulation
- History of head injury
- History of seizures or epilepsy
- Currently pregnant
- Use of medications that may change brain motor excitability or increase seizure risk
- Skull abnormalities, fractures, or recurring unexplained headaches
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Health San Antonio- Dept. of Physical Therapy
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
A
Anjali Sivaramakrishnan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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