Actively Recruiting

Phase Not Applicable
FEMALE
NCT05585164

Engage & Connect: A Psychotherapy for Postpartum Depression

Led by Weill Medical College of Cornell University · Updated on 2025-09-25

60

Participants Needed

1

Research Sites

399 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This randomized controlled trial compares a novel psychotherapy, Engage \& Connect, with a Symptom Review and Psychoeducation intervention, tailored to reduce postpartum depression. The study includes 9-weeks interventions, delivered remotely. It will examine changes in social isolation, processing of social rewards and depression severity over 9 weeks of treatment.

CONDITIONS

Official Title

Engage & Connect: A Psychotherapy for Postpartum Depression

Who Can Participate

FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Up to 1 year post-delivery
  • Edinburgh Postnatal Depression Scale (EPDS) score 60 10
  • Off antidepressants or on a stable dose of an antidepressant for 8 weeks and do not intend to change the dose in the next 10 weeks
  • Capacity to provide consent for research assessment and treatment
  • Speaks English proficiently
Not Eligible

You will not qualify if you...

  • Intent or plan to attempt suicide in the near future
  • Ongoing psychotherapy more than once every 8 weeks or during the intervention
  • Active substance abuse or dependence
  • Severe fetal anomalies, stillbirth or infant death at enrollment for the index pregnancy
  • History or presence of psychiatric diagnoses other than major depressive disorder without psychotic features, generalized anxiety disorder, persistent depressive disorder, or specific phobia
  • Use of psychotropic drugs or cholinesterase inhibitors other than use of 64 0.5 mg of lorazepam daily up to seven times per week

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Weill Cornell Medicine

New York, New York, United States, 10022

Actively Recruiting

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Research Team

N

Nili Solomonov, PhD

CONTACT

M

Maddy Schier

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

2

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