Actively Recruiting
Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors
Led by Second Affiliated Hospital of Guangzhou Medical University · Updated on 2024-06-25
40
Participants Needed
1
Research Sites
730 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital of Guangzhou Medical University
Lead Sponsor
G
Guangdong Zhaotai InVivo Biomedicine Co. Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Tumor infiltration lymphocytes (TILs) have been harvested from advanced cancer patients and constructed to knockout PD1 gene and express scFvs against both PD1 and CTALA4 and CARs against various antigens, followed by transfusion into the patients. The safety, tolerance, and preliminary clinical efficacy of the TILs will be evaluated.
CONDITIONS
Official Title
Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with advanced cancers that have not responded to current therapies
- Life expectancy greater than 12 weeks
- Adequate heart, lung, liver, and kidney functions
- Ability to undergo tumor biopsy or cancerous effusion collection
- Provided informed consent understood and signed by patient or guardian
You will not qualify if you...
- Previous gene therapy treatment
- Severe virus infections such as HBV, HCV, HIV, or known HIV positivity
- Active infections caused by bacteria, viruses, or fungi
- Other severe diseases deemed inappropriate by investigators
- Pregnant or breastfeeding women
- Receiving systemic steroid treatment at or above 0.5 mg prednisone equivalent/kg/day
- Other conditions deemed inappropriate by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510260
Actively Recruiting
Research Team
Z
Zhenfeng Zhang, MD, PhD
CONTACT
B
Bingjia He, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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