Association between COPD and Stage of Lung Cancer Diagnosis: A Population-Based Study.
Stacey J Butler, Alexander V Louie, Rinku Sutradhar...
https://pubmed.ncbi.nlm.nih.gov/37504331/Actively Recruiting
Led by Ditte Krag-Hansen · Updated on 2026-04-22
280
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating how early diagnosis and optimal treatment of Chronic Obstructive Pulmonary Disease COPD affect health outcomes in patients undergoing evaluation for suspected lung cancer. This study highlights the frequent coexistence of COPD and lung cancer, mainly due to shared risk factors like smoking. It aims to improve management of both diseases by focusing on integrated care approaches, potentially enhancing treatment tolerance, reducing complications, and improving overall survival. Participants are randomly assigned to either usual care or tailored COPD consultations following GOLD guidelines. The tailored consultations include pharmacological management, smoking cessation support, pulmonary rehabilitation referrals, nutritional assessment, cardiovascular evaluation, and sleep apnea assessment as needed. This is an open-label randomized controlled trial conducted at the Lung Cancer Investigation Unit at Lillebaelt Hospital Vejle. During the study, participants undergo assessments at baseline, 3 months, and 6 months, including the COPD Assessment Test CAT score, weight, height, BMI, 1-minute sit-to-stand test, and questionnaires on health status, anxiety, and depression. Researchers also monitor smoking cessation, exacerbations, hospitalizations, postoperative recovery, mortality, adverse events, and overall survival to evaluate the impact of early COPD management. The total study duration for participants spans 6 months with multiple follow-ups.
CONDITIONS
Enhanced COPD Management in Suspected Lung Cancer Patients
D
Ditte Krag-Hansen, MD, PhD student
M
Morten Hornemann Borg, MD, PhD, Chief consultant
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Ditte Krag-Hansen
Lead Sponsor
AstraZeneca
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants receive tailored COPD consultations including assessment and treatment according to GOLD guidelines, such as pharmacological management, smoking cessation support, and referrals to pulmonary rehabilitation, nutritional, cardiovascular, and sleep apnea evaluations as appropriate.
Visits at baseline, 3 months, and 6 months
Duration - 6 months
Participants undergoing usual lung cancer diagnostic evaluation without additional COPD intervention are observed during their lung cancer work-up.
Visits at baseline, 3 months, and 6 months
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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Lead Sponsor
AstraZeneca
Collaborating Sponsor