Pilot Study of Enhanced Recovery After Surgery Using Oral Antibiotics Post-Laparoscopic Appendectomy for Complicated Appendicitis in Adults

What this Trial Is About

Researchers are evaluating an enhanced recovery protocol for adults with complicated appendicitis who undergo laparoscopic appendectomy. The study aims to assess whether discharging patients home on an oral antibiotic regimen for three days after surgery is feasible and safe. Safety will be measured by tracking postoperative infections and readmission rates within 30 days. This pilot study is exploratory and sponsored by Cedars-Sinai Medical Center. Participants will receive oral antibiotics at home for three days instead of staying hospitalized for intravenous antibiotics after their laparoscopic appendectomy. The study includes patients diagnosed with complicated appendicitis, such as perforated, gangrenous, suppurative appendicitis, or iatrogenic appendix perforation, confirmed during surgery. Patients must meet discharge criteria from the post-anesthesia care unit to be eligible. During the study, participants will be monitored for adherence to postoperative instructions and any infectious complications. Researchers will evaluate compliance, safety outcomes, and the need for hospital readmission within 30 days after surgery. The total study period includes follow-up assessments during this 30-day postoperative window to observe recovery and complications.

Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis