Actively Recruiting

Phase Not Applicable
Age: 60Years +
All Genders
ID06000475

Enhancing Memory in Cognitive Processing Therapy for Older Adults With PTSD

Led by VA Office of Research and Development · Updated on 2025-10-14

30

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to improve psychotherapy for older adults with posttraumatic stress disorder (PTSD), especially Veterans, who often experience memory problems that reduce the benefit of treatments like cognitive processing therapy (CPT). Since memory deficits can affect how well patients learn and remember therapy content, this study tests adding a Memory Support intervention to CPT. The goal is to develop new approaches that help improve functioning for people with PTSD by enhancing how they learn therapy skills. The study compares standard CPT with a modified version that includes intentional strategies to boost memory and learning of therapy content. The study will be done in phases: first, modifying the CPT manual with expert and Veteran feedback; next, refining the treatment through a small case series; and finally, conducting a small randomized trial with 20 older Veterans to assess feasibility, acceptability, and initial effects. The Memory Support techniques aim to help patients better encode and retrieve therapy skills. Participants will receive therapy over 12 to 16 weeks while researchers assess symptoms using the PTSD Checklist-5. The study will monitor how well participants engage, complete treatment, and respond to therapy. This trial focuses on older Veterans with PTSD and memory challenges, tracking their progress and outcomes to inform future larger studies. The total participation time aligns with the treatment duration and includes symptom and functional outcome assessments.

CONDITIONS

Brief Title

Enhancing Memory in CPT for PTSD

Who Can Participate

Age: 60Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Veterans diagnosed with PTSD by Clinician Administered PTSD Scale (CAPS-5)
  • Age 60 years or older
Not Eligible

You will not qualify if you...

  • Daily benzodiazepine use
  • Bipolar or psychotic disorders
  • Current suicidal ideation with plan or intent
  • Current moderate or severe substance use disorder not in remission for over 1 month
  • Severe traumatic brain injury
  • Dementia indicated by Montreal Cognitive Assessment (MoCA)
  • Other disorders severely limiting study participation

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - 12 to 16 weeks

Participants receive Cognitive Processing Therapy (CPT) or CPT combined with Memory Support to enhance learning and memory of therapy content.

Weekly visits for up to 16 weeks

Trial Site Locations

Total: 1 location

1

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

Philadelphia, Pennsylvania, United States, 19104-4551

Actively Recruiting

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Research Team

J

James C Scott, PhD

R

Richard A Moore

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

2

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