Actively Recruiting
Enhancing Memory in Cognitive Processing Therapy for Older Adults With PTSD
Led by VA Office of Research and Development · Updated on 2025-10-14
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to improve psychotherapy for older adults with posttraumatic stress disorder (PTSD), especially Veterans, who often experience memory problems that reduce the benefit of treatments like cognitive processing therapy (CPT). Since memory deficits can affect how well patients learn and remember therapy content, this study tests adding a Memory Support intervention to CPT. The goal is to develop new approaches that help improve functioning for people with PTSD by enhancing how they learn therapy skills. The study compares standard CPT with a modified version that includes intentional strategies to boost memory and learning of therapy content. The study will be done in phases: first, modifying the CPT manual with expert and Veteran feedback; next, refining the treatment through a small case series; and finally, conducting a small randomized trial with 20 older Veterans to assess feasibility, acceptability, and initial effects. The Memory Support techniques aim to help patients better encode and retrieve therapy skills. Participants will receive therapy over 12 to 16 weeks while researchers assess symptoms using the PTSD Checklist-5. The study will monitor how well participants engage, complete treatment, and respond to therapy. This trial focuses on older Veterans with PTSD and memory challenges, tracking their progress and outcomes to inform future larger studies. The total participation time aligns with the treatment duration and includes symptom and functional outcome assessments.
CONDITIONS
Brief Title
Enhancing Memory in CPT for PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans diagnosed with PTSD by Clinician Administered PTSD Scale (CAPS-5)
- Age 60 years or older
You will not qualify if you...
- Daily benzodiazepine use
- Bipolar or psychotic disorders
- Current suicidal ideation with plan or intent
- Current moderate or severe substance use disorder not in remission for over 1 month
- Severe traumatic brain injury
- Dementia indicated by Montreal Cognitive Assessment (MoCA)
- Other disorders severely limiting study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 to 16 weeks
Participants receive Cognitive Processing Therapy (CPT) or CPT combined with Memory Support to enhance learning and memory of therapy content.
Weekly visits for up to 16 weeks
Trial Site Locations
Total: 1 location
1
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Philadelphia, Pennsylvania, United States, 19104-4551
Actively Recruiting
Research Team
J
James C Scott, PhD
R
Richard A Moore
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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