Actively Recruiting
Enhancing Physical Function in Older Adults With Chronic Kidney Disease
Led by Wake Forest University Health Sciences · Updated on 2025-12-31
30
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.
CONDITIONS
Official Title
Enhancing Physical Function in Older Adults With Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic kidney disease stages 3-5
- Capacity to complete physical exercise
- Lives within 20 miles of Wake Forest Reynolda Campus
- Fluent English speaker
- Does not plan to travel outside of home area for an extended period of time during study
- Willing to be randomized to either intervention group
You will not qualify if you...
- Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
- Dependent on a wheelchair
- Current participation in a resistance training program
- Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months
- Absolute contraindications to exercise testing according to ACSM:
Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection
- Parkinson's disease
- Respiratory disease requiring oxygen
- Cancer requiring treatment
- Currently receiving physical therapy or cardiopulmonary rehabilitation
- Type I or insulin dependent Type II Diabetes
- Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
- Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence
AI-Screening
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Trial Site Locations
Total: 1 location
1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
J
Jenna Lauderback
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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