Actively Recruiting
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
Led by Baylor College of Medicine · Updated on 2026-02-03
306
Participants Needed
1
Research Sites
183 weeks
Total Duration
On this page
Sponsors
B
Baylor College of Medicine
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare two different intensive formats of delivering cognitive-behavioral treatment for people with PTSD and anxiety disorders. The main questions it aims to answer are: * Is iTCBT delivered in individual and group formats more effective than TAU in improving anxiety symptoms and quality of life? * For treatment non-responders, is iTCBT-Enhanced more effective than TAU improving anxiety symptoms and quality of life? * Does iTCBT-Individual produce a larger improvement in anxiety and quality of life compared with iTCBT-Group? Participants will undergo several assessments throughout the course of the study. Based on randomization, they will receive: (1) iTCBT in an individual format over a 2-week period, (2) iTCBT in a group format over a 2-day period, or (3) usual care. Those who do not show a response to treatment will receive 4 additional individual therapy sessions.
CONDITIONS
Official Title
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veteran or service member aged 18 years or older
- Current diagnosis of at least one anxiety-based disorder including PTSD, panic disorder, social anxiety disorder, generalized anxiety disorder, other specified trauma- and stressor-related disorder, other specified anxiety disorder, or unspecified anxiety disorder based on ADIS-5
- Moderate-to-poor life enjoyment and satisfaction with a score of 47 or lower on the QLES-Q-SF
- Stable psychotropic medication use for at least 4 weeks before joining the study
- Willingness to be randomized to a treatment group
You will not qualify if you...
- Active symptoms of mania or psychosis at baseline according to ADIS-5
- Depression with active suicidal thoughts and intent that would prevent treatment as assessed by ADIS-5 and BDI-II
- Moderate-to-severe cognitive impairment with SLUMS score below 20
- Unwillingness to reduce or limit substance or alcohol use during treatment if comorbid substance/alcohol use or dependence is present
- Currently receiving transdiagnostic CBT targeting the study disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Michael E. DeBakey VA Medical Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
E
Ellen Teng, PhD
CONTACT
K
Keri Bayley, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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