Actively Recruiting
Enhancing Recovery in Non-Traumatic Spinal Cord Injury: Implementation of an Integrated Program for the Assessment of Rehabilitation Therapies
Led by Western University, Canada · Updated on 2024-03-28
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with degenerative spinal cord compression, a form of spinal cord injury that may be reversible. The study aims to understand how brain changes and recovery of neurological function occur after spinal cord compression, especially focusing on how rehabilitation therapy may boost brain plasticity and improve recovery. This research combines clinical care, surgery, and rehabilitation with advanced brain imaging techniques to explore these effects. Participants in this randomized, double-blind study will undergo spine decompression surgery. After surgery, they will be assigned to one of two groups: one receiving individualized occupational therapy rehabilitation from week 4 to week 12 post-surgery, and the other not receiving rehabilitation. The study compares neurological recovery and brain changes between these groups over time. Throughout the study, participants will be evaluated before surgery and at 4 weeks, 6 weeks, and 6 months afterward. Assessments include brain imaging to measure metabolic and functional changes in motor brain areas, and clinical tests evaluating strength, sensation, hand function, and overall neurological status. Additional questionnaires will assess quality of life and disability. Participants must be able to undergo MRI and attend all follow-up visits, with total participation lasting up to 6 months after surgery.
CONDITIONS
Brief Title
Enhancing Recovery in Non-Traumatic Spinal Cord Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Right-handed
- History of progressive neurological deficits less than 24 months
- Eligible for MRI scanning
- Able to read and speak English fluently
You will not qualify if you...
- Having any other neurological disorder or systemic disease that can impair neurological function
- Not fluent in reading and speaking English
- Being claustrophobic
- Unable to follow simple task instructions and maintain standardized movements
- Unable to return for all follow-up imaging and rehabilitation sessions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From week 4 post-surgery until week 12
Participants who have undergone decompression surgery receive occupational therapy rehabilitation individualized to their needs starting from week 4 post-surgery until week 12.
Weekly visits for up to 8 weeks
Duration - Up to 6 months after surgery
Participants are monitored with assessments and imaging at multiple time points after treatment to evaluate recovery and neurological function.
Visits at pre-surgery, 4 weeks, 6 weeks, and 6 months
Trial Site Locations
Total: 1 location
1
LHSC - University Hospital
London, Ontario, Canada, N6A 5A5
Actively Recruiting
Research Team
S
Sarah Detombe, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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