Actively Recruiting
Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.
Led by Pravat Mandal · Updated on 2026-05-04
12
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
Sponsors
P
Pravat Mandal
Lead Sponsor
W
Waste Connections Inc
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is designed l to evaluate the effects of GGC oral supplementation in early Parkinson's disease (PD) patients. The main objectives of the study are to evaluate: 1. To study the enrichment of master antioxidant, glutathione (GSH) levels in brain and blood of these PD patients compared to baseline due to GGC supplementation. 2. To study the changes in motor function, cognitive skills in PD patients due to GGC oral supplementation 3. To study impact of GGC on gut health on the PD patients.
CONDITIONS
Official Title
Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed Parkinson's Disease diagnosis.
- Montreal Cognitive Assessment (MoCA) greater than or equal to 26.
- Age 50 to 80 years.
- Ability to read and write in English.
You will not qualify if you...
- Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments in the eyes, skin, or body.
- Subjects with claustrophobia.
- Patients with a clinical diagnosis of Parkinson's disease dementia or dementia with Lewy bodies.
- Subjects with a history of cancer.
- Subjects with active psychosis or delirium.
- Subjects with chronic kidney (creatinine > 1.5mg/dL) or liver disease (AST 21 1.5 ULN; ALT 21 1.5 ULN) within 30 days prior to enrolment.
- Subjects on antioxidant therapy (ashwagandha, gingko biloba or N-acetylcysteine) or illicit drug abuse/dependence (cocaine, heroin, marijuana, or fentanyl).
- Subjects with previous traumatic head injury.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UPMC Presbyterian Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
P
Pravat K MANDAL, PHD
CONTACT
N
Nazia Pillar, M.S
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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