Comparison of Feeding Methods in Patients With Moderate to Severe ARDS on Prone Ventilation Randomized Study of Nasogastric Versus Nasojejunal Enteral Nutrition

What this Trial Is About

Researchers are evaluating the impact, safety, and practical use of two methods of delivering enteral nutrition in patients with moderate to severe Acute Respiratory Distress Syndrome ARDS who require ventilation in the prone position. The study is designed as a pilot randomized controlled trial to compare nutrition delivered via a nasogastric tube versus a nasojejunal tube. This research aims to understand which feeding method better achieves nutrition goals and how it affects patient outcomes during prone ventilation. Participants will be randomly assigned to one of two groups one receiving enteral nutrition through a nasojejunal tube postpyloric feeding and the other through a nasogastric tube gastric feeding. The intervention involves placing the respective feeding tubes to provide nutrition. The study will monitor participants over several time frames to assess nutrition intake and clinical outcomes related to infections, ventilator use, ICU stay, and mortality rates. During the study, researchers will measure the cumulative ratio of enteral nutrition intake to target over 7 days as the primary outcome. Secondary outcomes include rates of hospital-acquired infections, ventilator-free days within 28 days, length of ICU stay, ICU mortality, and mortality rates at 28 and 60 days. The study will also track enteral nutrition intolerance and daily nutrition intake rates. Participants will be followed for up to 24 weeks for some outcomes, with detailed safety and effectiveness monitoring throughout the trial period.

Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS