Actively Recruiting
The Enteric Nervous System in Spinal Cord Injury: Study of the Enteric Nervous System and the Intestinal Epithelial Barrier Via Colonic Biopsies in Spinal Cord Injury Patients
Led by Nantes University Hospital · Updated on 2026-04-17
40
Participants Needed
2
Research Sites
218 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn more about the enteric nervous system (ENS) and the intestinal epithelial barrier (IEB) in patients with spinal cord injury (SCI). The main questions it aims to answer are : * to characterize the functional (permeability, serotonin production, enteric neuronal phenotype, etc.), proteomic (junction molecules) and transcriptomic (inflammation genes, neuromediator expression, etc.) remodeling of the colonic mucosa and ENS in SCI patients, in comparison with control data. * to correlate intestinal permeability (and all remodeling parameters) with the type of neurological impairment i.e. the neurological level of the lesion, quantification of neurological impairment (motor and sensory scores) and the completeness and incompleteness of a lesion. * to identify a link with disease severity markers * to identify therapeutic targets that could subsequently be tested in the animal model before being proposed in clinical trials. Participants will have colonic biopsies taken following a colonoscopy/rectosigmoidoscopy previously indicated for spinal cord injured patients. Biopsies will be obtained from the right and left colon.
CONDITIONS
Official Title
The Enteric Nervous System in Spinal Cord Injury: Study of the Enteric Nervous System and the Intestinal Epithelial Barrier Via Colonic Biopsies in Spinal Cord Injury Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed consent to participate
- Aged between 18 and 80 years
- Acquired traumatic or non-traumatic spinal cord injury (patients)
- Indication for colonoscopy or rectosigmoidoscopy at Nantes University Hospital Gastroenterology Department (patients)
- Eligible for French social security (patients)
- Enrolled in the COSCINUS cohort (patients)
- No neurological pathology and indication for screening or preventive colonoscopy due to personal or family history of polyps or familial colon cancer (controls)
- Signed consent (controls)
- Aged between 18 and 80 years (controls)
You will not qualify if you...
- Emergency situations or deprived of liberty
- Not covered by social security
- Under legal protection
- Suffering from inflammatory digestive disease
- On anticoagulant therapy without possibility of stopping or switching
- Contraindications to colonoscopy or rectosigmoidoscopy
- Pregnant or breastfeeding
- Treatment with anticoagulants or antiaggregants (controls)
- Coagulation disorder (controls)
- Abnormal colonoscopy findings other than benign polyps (controls)
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Trial Site Locations
Total: 2 locations
1
CHU de Nantes service de gastroentérologie
Nantes, France, 44000
Not Yet Recruiting
2
CHU de Nantes service MPR
Nantes, France, 44000
Actively Recruiting
Research Team
C
Chloé LEFEVRE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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