Large Study on How Environment and Lifestyle Affect Infertility Treatment Success Tracking IVF and Assisted Reproductive Technology Outcomes Among Adults Using Their Own Eggs or Sperm

What this Trial Is About

Researchers are examining how everyday environmental exposures and personal lifestyle habits might influence the success rates of fertility treatments such as assisted reproductive technology ART. This large-scale observational study focuses on couples experiencing infertility and undergoing ART, aiming to understand how factors like contact with plastic-related pollutants, air pollution, diet, and stress may relate to achieving pregnancy and live birth. The study will follow about 5,000 couples in Hunan, China, with strict confidentiality and ethical oversight. Participants will be grouped based on their exposure to environmental pollutants related to plastic products or lack thereof. During their routine fertility treatment, couples will provide biological samples like blood and urine and complete questionnaires about their health, lifestyle, and environmental factors. These data will be collected throughout their standard ART process, with treatment outcomes tracked anonymously over time. Throughout the study, researchers will monitor participants treatment success, focusing on the live birth rate following the first ART cycle within a 24-month period from treatment initiation. Participants will engage in typical clinical visits for sample collection and questionnaire completion, with no additional interventions beyond their standard care. The goal is to identify environmental and behavioral factors that may affect ART outcomes, helping guide future patient care and public health recommendations.

Environmental and Behavioral Factors in Infertility and ART Outcomes