Actively Recruiting
A Large-Scale Prospective Cohort Study on the Association of Environmental Exposures and Behavioral Factors With Infertility and Assisted Reproductive Technology Success Rates
Led by The Third Xiangya Hospital of Central South University · Updated on 2026-02-03
5000
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining how everyday environmental exposures and personal lifestyle habits might influence the success rates of fertility treatments such as assisted reproductive technology (ART). This large-scale observational study focuses on couples experiencing infertility and undergoing ART, aiming to understand how factors like contact with plastic-related pollutants, air pollution, diet, and stress may relate to achieving pregnancy and live birth. The study will follow about 5,000 couples in Hunan, China, with strict confidentiality and ethical oversight. Participants will be grouped based on their exposure to environmental pollutants related to plastic products or lack thereof. During their routine fertility treatment, couples will provide biological samples like blood and urine and complete questionnaires about their health, lifestyle, and environmental factors. These data will be collected throughout their standard ART process, with treatment outcomes tracked anonymously over time. Throughout the study, researchers will monitor participants' treatment success, focusing on the live birth rate following the first ART cycle within a 24-month period from treatment initiation. Participants will engage in typical clinical visits for sample collection and questionnaire completion, with no additional interventions beyond their standard care. The goal is to identify environmental and behavioral factors that may affect ART outcomes, helping guide future patient care and public health recommendations.
CONDITIONS
Brief Title
Environmental and Behavioral Factors in Infertility and ART Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 46 who use their own eggs; men aged 18 to 55 who use their own sperm
- Diagnosed with infertility
- Clear medical history showing duration of ongoing infertility
- Voluntarily agree to participate and sign informed consent
You will not qualify if you...
- Artificial insemination patients with any contraindications: female sperm-egg combination disorder caused by tubal factors, acute infections of reproductive or urinary systems, sexually transmitted diseases, genetic diseases, severe physical or mental disorders, history of infants with congenital defects caused by female, exposure to teratogenic radiation, toxins, or drugs, or alcoholism or drug abuse
- First- and second-generation IVF patients with any contraindications: acute infections or sexually transmitted diseases in gamete providers, exposure to teratogenic radiation, toxins, or drugs, alcoholism or drug abuse, unviable uterus, or severe physical illnesses preventing pregnancy
- No embryo transfer performed after egg retrieval
- More than 180 days passed since egg retrieval and frozen embryo transfer performed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 24 months from the initiation of the first ART cycle
Participants are observed to assess the association of environmental exposures and behavioral factors with infertility and assisted reproductive technology success rates.
Trial Site Locations
Total: 1 location
1
Reproductive Medicine Center of Xiangya Third Hospital of Central South University
Changsha, Hunan, China, 410013
Actively Recruiting
Research Team
X
Xingping Zhao
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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