Model of Diseases Related to Environmental Exposure to Heavy Metals, Nanoparticles and Emergent Contaminants Using a Digital Platform of Clinical and Bio-humoral Data: the Way to Susceptibility/Risk Biomarker [MATRIOSKA Study] - The Seed.

What this Trial Is About

This research aims to collect and compare environmental, biological, and clinical data from patients with allergic contact dermatitis (ACD) and systemic metal allergic syndromes caused by exposure to heavy metals, nanoparticles, and emerging contaminants, as well as from healthy individuals. The study investigates whether these data differ between affected patients and healthy subjects by analyzing factors such as serum and urine metal concentrations, patch test results, respiratory parameters, and markers of oxidative stress and gut exposure. Participants are divided into three groups: those with systemic allergic syndrome related to metals, those with ACD due to metal exposure, and healthy volunteers without such exposure. All participants will undergo various assessments including measurement of serum and urine levels of metals like nickel, cobalt, chromium, palladium, molybdenum, aluminium, and copper. They will also have patch tests for these metals, within-breath oscillometry tests to assess respiratory function, and blood tests to measure serum zonulin and protein oxidation products. During the study, participants will be monitored through diagnostic tests performed at enrollment to evaluate metal exposure and biological responses. The main outcomes include serum and urinary metal concentrations, patch test results, respiratory impedance measures, and serum levels of zonulin and protein oxidation products. The study does not specify treatment but focuses on collecting data to understand susceptibility and risk factors. Participation involves a single assessment visit, with no long-term follow-up mentioned.

Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases